Complex formation between some metals and a quinolone family member (ciprofloxacin)

Iztok Turel, Nataša Bukovec, E. Farkas

Research output: Contribution to journalArticle

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Abstract

Some metal [Ca(II), Co(II), Ni(II), Cu(II), Zn(II), Al(III) and Fe(III)] complexes of the quinolone family member (ciprofloxacin = cf) were studied by potentiometric and spectroscopic methods in solution. The results of EPR and polarographic methods are also included. The titration curves for the metal ion-ciprofloxacin were evaluated by assuming all possible models. It was found that a lot of protonated complexes are formed before precipitation in the systems studied. The UV-vis results in the Cu(II)-Cf system showed that in the more acidic region a 1:1 complex is favoured, whereas a 1:2 complex prevailed at higher pH values. The coordination of the second ligand is somewhat more favoured than that of the first ligand, and it seems probable that the 1:1 complex is more distorted. Some ternary complexes (Cu(II)-cf-2.2′-bipyridyl, -glycine and -tyrosine] were studied as well. From the ΔlogK value, it was deduced that the formation of the mixed ligand complex in the system Cu(II)-cf-2.2′-bipyridyl is favoured due to back-coordination.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalPolyhedron
Volume15
Issue number2
DOIs
Publication statusPublished - Jan 1996

Fingerprint

Quinolones
Ciprofloxacin
2,2'-Dipyridyl
Metals
Ligands
ligands
metals
tyrosine
glycine
Titration
titration
Glycine
Metal ions
Paramagnetic resonance
Tyrosine
Amino acids
metal ions
Ions
curves

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Complex formation between some metals and a quinolone family member (ciprofloxacin). / Turel, Iztok; Bukovec, Nataša; Farkas, E.

In: Polyhedron, Vol. 15, No. 2, 01.1996, p. 269-275.

Research output: Contribution to journalArticle

Turel, Iztok ; Bukovec, Nataša ; Farkas, E. / Complex formation between some metals and a quinolone family member (ciprofloxacin). In: Polyhedron. 1996 ; Vol. 15, No. 2. pp. 269-275.
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