Abstract
The interaction between [Ru(η6-p-cym)(H2O) 3]2+ and (O,O) type chelators with different basicity of the donor atoms was studied using combined pH-potentiometric, 1H-NMR and ESI-TOF-MS techniques. The studied nine ligands are building blocks of reported complexes with antitumor activity or may model (O,O) donor serum components capable of interacting with the administered half-sandwich ruthenium(ii) type drug. Composition and stability constants of the [Ru(η6-p-cym)(O,O)Y] type species (Y: H2O or OH -) were determined (T = 25.0 °C; I = 0.20 M (KCl)) and the metal ion binding strengths of the ligands are discussed. It was found that ligands with two low basicity O donors (oxalic and cyclobutane-1,1-dicarboxylic acid) bind the metal ion at acidic conditions but are not able to prevent the hydrolysis at physiologically relevant conditions. Ligands with one low and one high basicity O donor (lactic and salicylic acid) are weak binders for Ru(η6-p-cym)(H2O)3]2+. Pyrone or pyridinone based ligands are capable of binding the metal ion over a wide pH range and no hydrolysis product is detectable at pH = 7.4. The obtained speciation models may help in the rationalization of the biological activity of such complexes and provide a deeper insight into the solution behaviour of half-sandwich Ru(ii) complexes with potential anticancer activity.
Original language | English |
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Pages (from-to) | 10272-10278 |
Number of pages | 7 |
Journal | Dalton Transactions |
Volume | 39 |
Issue number | 42 |
DOIs | |
Publication status | Published - Nov 14 2010 |
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ASJC Scopus subject areas
- Inorganic Chemistry
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Complex formation between Ru(η6-p-cym)(H2O) 3]2+ and (O,O) donor ligands with biological relevance in aqueous solution. / Bíró, Linda; Farkas, E.; Buglyó, P.
In: Dalton Transactions, Vol. 39, No. 42, 14.11.2010, p. 10272-10278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Complex formation between Ru(η6-p-cym)(H2O) 3]2+ and (O,O) donor ligands with biological relevance in aqueous solution
AU - Bíró, Linda
AU - Farkas, E.
AU - Buglyó, P.
PY - 2010/11/14
Y1 - 2010/11/14
N2 - The interaction between [Ru(η6-p-cym)(H2O) 3]2+ and (O,O) type chelators with different basicity of the donor atoms was studied using combined pH-potentiometric, 1H-NMR and ESI-TOF-MS techniques. The studied nine ligands are building blocks of reported complexes with antitumor activity or may model (O,O) donor serum components capable of interacting with the administered half-sandwich ruthenium(ii) type drug. Composition and stability constants of the [Ru(η6-p-cym)(O,O)Y] type species (Y: H2O or OH -) were determined (T = 25.0 °C; I = 0.20 M (KCl)) and the metal ion binding strengths of the ligands are discussed. It was found that ligands with two low basicity O donors (oxalic and cyclobutane-1,1-dicarboxylic acid) bind the metal ion at acidic conditions but are not able to prevent the hydrolysis at physiologically relevant conditions. Ligands with one low and one high basicity O donor (lactic and salicylic acid) are weak binders for Ru(η6-p-cym)(H2O)3]2+. Pyrone or pyridinone based ligands are capable of binding the metal ion over a wide pH range and no hydrolysis product is detectable at pH = 7.4. The obtained speciation models may help in the rationalization of the biological activity of such complexes and provide a deeper insight into the solution behaviour of half-sandwich Ru(ii) complexes with potential anticancer activity.
AB - The interaction between [Ru(η6-p-cym)(H2O) 3]2+ and (O,O) type chelators with different basicity of the donor atoms was studied using combined pH-potentiometric, 1H-NMR and ESI-TOF-MS techniques. The studied nine ligands are building blocks of reported complexes with antitumor activity or may model (O,O) donor serum components capable of interacting with the administered half-sandwich ruthenium(ii) type drug. Composition and stability constants of the [Ru(η6-p-cym)(O,O)Y] type species (Y: H2O or OH -) were determined (T = 25.0 °C; I = 0.20 M (KCl)) and the metal ion binding strengths of the ligands are discussed. It was found that ligands with two low basicity O donors (oxalic and cyclobutane-1,1-dicarboxylic acid) bind the metal ion at acidic conditions but are not able to prevent the hydrolysis at physiologically relevant conditions. Ligands with one low and one high basicity O donor (lactic and salicylic acid) are weak binders for Ru(η6-p-cym)(H2O)3]2+. Pyrone or pyridinone based ligands are capable of binding the metal ion over a wide pH range and no hydrolysis product is detectable at pH = 7.4. The obtained speciation models may help in the rationalization of the biological activity of such complexes and provide a deeper insight into the solution behaviour of half-sandwich Ru(ii) complexes with potential anticancer activity.
UR - http://www.scopus.com/inward/record.url?scp=77958032027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958032027&partnerID=8YFLogxK
U2 - 10.1039/c0dt00469c
DO - 10.1039/c0dt00469c
M3 - Article
C2 - 20922244
AN - SCOPUS:77958032027
VL - 39
SP - 10272
EP - 10278
JO - Dalton Transactions
JF - Dalton Transactions
SN - 1477-9226
IS - 42
ER -