Complex formation between Ru(η6-p-cym)(H2O) 3]2+ and (O,O) donor ligands with biological relevance in aqueous solution

Linda Bíró, E. Farkas, P. Buglyó

Research output: Contribution to journalArticle

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Abstract

The interaction between [Ru(η6-p-cym)(H2O) 3]2+ and (O,O) type chelators with different basicity of the donor atoms was studied using combined pH-potentiometric, 1H-NMR and ESI-TOF-MS techniques. The studied nine ligands are building blocks of reported complexes with antitumor activity or may model (O,O) donor serum components capable of interacting with the administered half-sandwich ruthenium(ii) type drug. Composition and stability constants of the [Ru(η6-p-cym)(O,O)Y] type species (Y: H2O or OH -) were determined (T = 25.0 °C; I = 0.20 M (KCl)) and the metal ion binding strengths of the ligands are discussed. It was found that ligands with two low basicity O donors (oxalic and cyclobutane-1,1-dicarboxylic acid) bind the metal ion at acidic conditions but are not able to prevent the hydrolysis at physiologically relevant conditions. Ligands with one low and one high basicity O donor (lactic and salicylic acid) are weak binders for Ru(η6-p-cym)(H2O)3]2+. Pyrone or pyridinone based ligands are capable of binding the metal ion over a wide pH range and no hydrolysis product is detectable at pH = 7.4. The obtained speciation models may help in the rationalization of the biological activity of such complexes and provide a deeper insight into the solution behaviour of half-sandwich Ru(ii) complexes with potential anticancer activity.

Original languageEnglish
Pages (from-to)10272-10278
Number of pages7
JournalDalton Transactions
Volume39
Issue number42
DOIs
Publication statusPublished - Nov 14 2010

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Ligands
Alkalinity
Metal ions
Hydrolysis
Cyclobutanes
Pyrones
Pyridones
Dicarboxylic Acids
Ruthenium
Salicylic Acid
Chelating Agents
Bioactivity
Binders
Nuclear magnetic resonance
Atoms
Chemical analysis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Inorganic Chemistry

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Complex formation between Ru(η6-p-cym)(H2O) 3]2+ and (O,O) donor ligands with biological relevance in aqueous solution. / Bíró, Linda; Farkas, E.; Buglyó, P.

In: Dalton Transactions, Vol. 39, No. 42, 14.11.2010, p. 10272-10278.

Research output: Contribution to journalArticle

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