Complex-formation and redox reactions of bilirubin and biliverdin with zinc(II), cadmium(II) and copper(II) ions

Imre Sóvágó, Béla Harman, Irén Kolozsvári, Ferenc Matyuska

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Transition metal complexes of bilirubin and biliverdin were studied spectrophotometrically, in DMSO and in a boric acid-NaOH buffer mixture at pH 10.5. In the zinc(II) and cadmium(II)- bilirubin systems, 2:1 complexes are formed. Both in aqueous and in DMSO medium, the copper(II) ion oxidizes bilirubin to biliverdin. With all three metal ions, biliverdin forms 1:1 complexes, the stabilities of which are higher than those of the corresponding bilirubin complexes. Accordingly, these metal ions accelerate the oxidative transformations of bilirubin.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalInorganica Chimica Acta
Issue number4
Publication statusPublished - Apr 1985


ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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