Complex attributes of lateral hypothalamic neurons in the regulation of feeding of alert rhesus monkeys

Zoltán Karádi, Yutaka Oomura, Hitoo Nishino, Thomas R. Scott, László Lénárd, Shuji Aou

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To elucidate the roles of glucose-sensitive (GS) and glucose-insensitive (GIS) cells of the lateral hypothalamic area (LHA), single neuron activity was recorded during 1) microelectrophoretic administration of chemicals, 2) a conditioned bar press feeding task, 3) gustatory, 4) olfactory, and 5) electrical brain stimulation. GS and GIS neurons showed different firing rate changes during phases of the task, and the responses were highly influenced by the palatability of the food and the motivational (hunger or satiety) state of the animal. The two groups of cells also differed in their responsiveness to gustatory and olfactory stimuli: GS neurons were more likely to respond to tastes and odors than GIS cells. Taste- and odor-responsive GS neurons were primarily suppressed by electrophoretically applied noradrenaline and were localized ventromedially within the LHA. The chemosensitive GIS cells, being organized along a dorsolateral axis, were especially excited by dopamine. The two sets of neurons had distinct connections with associative (orbitofrontal, prefrontal) cortical areas. GS and GIS cells, thus, appear to have differential and complex attributes in the control of feeding.

Original languageEnglish
Pages (from-to)933-939
Number of pages7
JournalBrain Research Bulletin
Volume25
Issue number6
DOIs
Publication statusPublished - Dec 1990

Keywords

  • Alert monkey
  • Catecholamines
  • Chemical senses
  • Feeding
  • Glucose-sensitive neurons
  • Hypothalamus
  • Orbitofrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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