Életmino{double acute}séget befolyásoló késo{double acute}i mellékhatások komplex felmérése - A debreceni modell

Translated title of the contribution: Complex assessment of late side effects affecting quality of life - The "Debrecen model"

Edit Bárdi, Zoltán Jenei, Ágnes Horváth, Timea Bodó, Marianna Bende, Laura Sándor, Ádám Riz, J. Kappelmayer, C. Kiss

Research output: Contribution to journalArticle

Abstract

As the outcome of childhood cancer improved substantially during the last 3 decades, the attitude of pediatric oncology has changed from "cure at any cost" to "cure at least cost". We investigated factors affecting quality of life in long-term survivors of childhood cancer in the in- and outpatient clinics of the Department of Pediatric Hematology-oncology, Institute of Pediatrics, Medical and Health Science Center, Debrecen. As a part of a comprehensive follow-up care program, we focused our attention on nephrotoxicity, osteoporosis and on cardiovascular morbidity. For long-term survivors of childhood cancer sensitive and cost-effective diagnostic algorithms were developed that can help in guiding secondary and tertiary prevention programs, in addition to assessing accurately the condition of patients. We found that anti-cancer treatments, including some of the supportive interventions, have adverse effects on glomerular (10%) and tubular functions (37%), impair the balance of bone resorption and formation (69%) and increase the frequency of cardiovascular risk factors (62%) in a significant proportion of patients. Our data confirm and extend the findings of other investigators and cooperative groups. In conclusion, we consider it important that the treatment plans of high-risk patients with cancer should be aimed at preserving the anticancer potential of therapy, without enhancing the frequency and severity of complications. The presented "Debrecen model" may help in achieving this goal and in increasing quality of life of long-term survivors of childhood cancer.

Original languageHungarian
Pages (from-to)110-116
Number of pages7
JournalMagyar Onkologia
Volume55
Issue number2
Publication statusPublished - 2011

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Quality of Life
Survivors
Neoplasms
Pediatrics
Tertiary Prevention
Costs and Cost Analysis
Aftercare
Hematology
Bone Resorption
Secondary Prevention
Ambulatory Care Facilities
Osteogenesis
Osteoporosis
Inpatients
Therapeutics
Research Personnel
Morbidity
Health

ASJC Scopus subject areas

  • Oncology

Cite this

Életmino{double acute}séget befolyásoló késo{double acute}i mellékhatások komplex felmérése - A debreceni modell. / Bárdi, Edit; Jenei, Zoltán; Horváth, Ágnes; Bodó, Timea; Bende, Marianna; Sándor, Laura; Riz, Ádám; Kappelmayer, J.; Kiss, C.

In: Magyar Onkologia, Vol. 55, No. 2, 2011, p. 110-116.

Research output: Contribution to journalArticle

Bárdi, E, Jenei, Z, Horváth, Á, Bodó, T, Bende, M, Sándor, L, Riz, Á, Kappelmayer, J & Kiss, C 2011, 'Életmino{double acute}séget befolyásoló késo{double acute}i mellékhatások komplex felmérése - A debreceni modell', Magyar Onkologia, vol. 55, no. 2, pp. 110-116.
Bárdi, Edit ; Jenei, Zoltán ; Horváth, Ágnes ; Bodó, Timea ; Bende, Marianna ; Sándor, Laura ; Riz, Ádám ; Kappelmayer, J. ; Kiss, C. / Életmino{double acute}séget befolyásoló késo{double acute}i mellékhatások komplex felmérése - A debreceni modell. In: Magyar Onkologia. 2011 ; Vol. 55, No. 2. pp. 110-116.
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