Prognosztikai faktorok komplex vizsgálata krónikus lymphocytás leukémiában

Translated title of the contribution: Complex analysis of prognostic factors in chronic lymphocytic leukemia

Béla Kajtár, Pál Jáksó, L. Kereskai, Ágnes Lacza, G. Méhes, Maria Anna Bodnár, J. Péter Dombi, Zoltán Gasztonyi, Miklós Egyed, János Laszló Iványi, G. Kovács, Éva Marton, Aranka Palaczki, Sándor Petz, Péter Tóth, Erzsébet Sziládi, Hajna Losonczy, László Pajor

Research output: Contribution to journalArticle

Abstract

Introduction: Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. Aims: The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. Methods: The mutation status of the IgH gene was evaluated in 160 cases. Results: In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnoramlities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11 q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes. Conclusions: The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.

Original languageHungarian
Pages (from-to)737-743
Number of pages7
JournalOrvosi Hetilap
Volume148
Issue number16
DOIs
Publication statusPublished - Apr 22 2007

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B-Cell Chronic Lymphocytic Leukemia
Genes
Mutation
Cytogenetics
Leukemia
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prognosztikai faktorok komplex vizsgálata krónikus lymphocytás leukémiában. / Kajtár, Béla; Jáksó, Pál; Kereskai, L.; Lacza, Ágnes; Méhes, G.; Bodnár, Maria Anna; Dombi, J. Péter; Gasztonyi, Zoltán; Egyed, Miklós; Iványi, János Laszló; Kovács, G.; Marton, Éva; Palaczki, Aranka; Petz, Sándor; Tóth, Péter; Sziládi, Erzsébet; Losonczy, Hajna; Pajor, László.

In: Orvosi Hetilap, Vol. 148, No. 16, 22.04.2007, p. 737-743.

Research output: Contribution to journalArticle

Kajtár, B, Jáksó, P, Kereskai, L, Lacza, Á, Méhes, G, Bodnár, MA, Dombi, JP, Gasztonyi, Z, Egyed, M, Iványi, JL, Kovács, G, Marton, É, Palaczki, A, Petz, S, Tóth, P, Sziládi, E, Losonczy, H & Pajor, L 2007, 'Prognosztikai faktorok komplex vizsgálata krónikus lymphocytás leukémiában', Orvosi Hetilap, vol. 148, no. 16, pp. 737-743. https://doi.org/10.1556/OH.2007.27943
Kajtár, Béla ; Jáksó, Pál ; Kereskai, L. ; Lacza, Ágnes ; Méhes, G. ; Bodnár, Maria Anna ; Dombi, J. Péter ; Gasztonyi, Zoltán ; Egyed, Miklós ; Iványi, János Laszló ; Kovács, G. ; Marton, Éva ; Palaczki, Aranka ; Petz, Sándor ; Tóth, Péter ; Sziládi, Erzsébet ; Losonczy, Hajna ; Pajor, László. / Prognosztikai faktorok komplex vizsgálata krónikus lymphocytás leukémiában. In: Orvosi Hetilap. 2007 ; Vol. 148, No. 16. pp. 737-743.
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abstract = "Introduction: Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. Aims: The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. Methods: The mutation status of the IgH gene was evaluated in 160 cases. Results: In 62{\%} of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78{\%} concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnoramlities were seen in 76{\%} of cases, the most frequent were del(13q) (57{\%}), trisomy 12 (15{\%}), del(11q) (12{\%}) and del(17p) (6{\%}). 95{\%} of cases with del(11 q) harbored non-mutated, 74{\%} of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes. Conclusions: The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.",
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T1 - Prognosztikai faktorok komplex vizsgálata krónikus lymphocytás leukémiában

AU - Kajtár, Béla

AU - Jáksó, Pál

AU - Kereskai, L.

AU - Lacza, Ágnes

AU - Méhes, G.

AU - Bodnár, Maria Anna

AU - Dombi, J. Péter

AU - Gasztonyi, Zoltán

AU - Egyed, Miklós

AU - Iványi, János Laszló

AU - Kovács, G.

AU - Marton, Éva

AU - Palaczki, Aranka

AU - Petz, Sándor

AU - Tóth, Péter

AU - Sziládi, Erzsébet

AU - Losonczy, Hajna

AU - Pajor, László

PY - 2007/4/22

Y1 - 2007/4/22

N2 - Introduction: Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. Aims: The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. Methods: The mutation status of the IgH gene was evaluated in 160 cases. Results: In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnoramlities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11 q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes. Conclusions: The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.

AB - Introduction: Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. Aims: The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. Methods: The mutation status of the IgH gene was evaluated in 160 cases. Results: In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnoramlities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11 q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes. Conclusions: The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.

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KW - Chronic lymphocytic leukemia

KW - Cytogenetics

KW - IgH mutation

KW - Prognostic markers

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