Complete Reversion of Cardiac Functional Adaptation Induced by Exercise Training

A. Oláh, Dalma Kellermayer, Csaba Mátyás, Balázs Tamás Németh, Árpád Lux, Lilla Szabó, Marianna Török, Mihály Ruppert, Anna Meltzer, Alex Ali Sayour, Kálmán Benke, István Hartyánszky, B. Merkely, T. Radovits

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE: Long-term exercise training is associated with characteristic cardiac adaptation, termed athlete’s heart. Our research group previously characterized in vivo left ventricular (LV) function of exercise-induced cardiac hypertrophy in detail in a rat model, however the effect of detraining on LV function is still unclear. We aimed at evaluating the reversibility of functional alterations of athlete’s heart after detraining. METHODS: Rats (n=16) were divided into detrained exercised (DEx) and detrained control (DCo) groups. Trained rats swam 200min/day for 12weeks, control rats were taken into water for 5min/day. After the training period both groups remained sedentary for 8weeks. We performed echocardiography at week 12 and 20 to investigate the development and regression of exercise-induced structural changes. LV pressure-volume analysis was performed to calculate cardiac functional parameters. LV samples were harvested for histological examination. RESULTS: Echocardiography showed robust LV hypertrophy after completing the training protocol (LVmass index: 2.61±0.08 DEx vs. 2.04±0.04g/kg DCo,p<0.05). This adaptation regressed after detraining (LVmass index: 2.01±0.03 vs. 1.97±0.05g/kg,n.s.), which was confirmed by post-mortem measured heart weight and histological morphometry. After the 8-week-long detraining period regression of the previously described exercise-induced cardiac functional alterations was observed (DEx vs. DCo): stroke volume (144.8±9.0 vs. 143.9±9.6μl, p=0.949), active relaxation (τ: 11.5±0.3 vs. 11.3±0.4ms, p=0.760), contractility (preload recruitable stroke work: 69.5±2.7 vs. 70.9±2.4mmHg, p=0.709) and mechanoenergetic (mechanical efficiency: 68.7±1.2 vs. 69.4±1.8%, p=0.742) enhancement reverted completely to control values. Myocardial stiffness remained unchanged, moreover no fibrosis was observed after the detraining period. CONCLUSION: Functional consequences of exercise-induced physiological LV hypertrophy completely regressed after 8weeks of deconditioning.

Original languageEnglish
JournalMedicine and Science in Sports and Exercise
DOIs
Publication statusAccepted/In press - Oct 14 2016

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Oláh, A., Kellermayer, D., Mátyás, C., Németh, B. T., Lux, Á., Szabó, L., Török, M., Ruppert, M., Meltzer, A., Sayour, A. A., Benke, K., Hartyánszky, I., Merkely, B., & Radovits, T. (Accepted/In press). Complete Reversion of Cardiac Functional Adaptation Induced by Exercise Training. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0000000000001127