Complete amino acid sequence of chicken cartilage link protein deduced from cDNA clones

F. Deak, I. Kiss, K. J. Sparks, W. S. Argraves, G. Hampikian, P. F. Goetinck

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

cDNA clones coding for chicken cartilage link protein were isolated and sequenced. The DNA sequence for the entire core polypeptide of the mature link protein and the predicted signal peptide consists of 1065 nucleotides. The deduced primary translation product (355 amino acids) has a molecular mass of 40.7 kDa; the calculated molecular mass of the mature link protein core polypeptide (340 amino acids) is 39.06 kDa. The DNA sequence contains two tandemly arranged repeat sequences that may code for repeated functional domains of link protein involved in binding to hyaluronic acid. The mRNAs for chicken link protein are 6.0, 5.8, and 3.0 kilobase pairs, and the difference between the sizes of the RNA species lies in the 3' untranslated region.

Original languageEnglish
Pages (from-to)3766-3770
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number11
Publication statusPublished - 1986

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Amino Acid Sequence
Chickens
Complementary DNA
Clone Cells
Amino Acids
Peptides
3' Untranslated Regions
Hyaluronic Acid
Protein Sorting Signals
Nucleotides
link protein
RNA
Messenger RNA

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Complete amino acid sequence of chicken cartilage link protein deduced from cDNA clones. / Deak, F.; Kiss, I.; Sparks, K. J.; Argraves, W. S.; Hampikian, G.; Goetinck, P. F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 11, 1986, p. 3766-3770.

Research output: Contribution to journalArticle

Deak, F. ; Kiss, I. ; Sparks, K. J. ; Argraves, W. S. ; Hampikian, G. ; Goetinck, P. F. / Complete amino acid sequence of chicken cartilage link protein deduced from cDNA clones. In: Proceedings of the National Academy of Sciences of the United States of America. 1986 ; Vol. 83, No. 11. pp. 3766-3770.
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