Complement system activation in obstructive sleep apnea

P. Horváth, David L. Tarnoki, Adam D. Tarnoki, K. Karlinger, Zsofia Lazar, Gyorgy Losonczy, Laszlo Kunos, Andras Bikov

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study the involvement of effector complement elements in obstructive sleep apnea, namely C3a, C5a and SC5b-9. Venous blood was collected in 50 patients with obstructive sleep apnea and 26 control subjects in the evening and the following morning. Plasma complement proteins were analysed with ELISA. Complement factor levels were compared between the two groups and correlated with clinical variables. Plasma C3a concentration was elevated in obstructive sleep apnea both in the evening (84.1 [0-338.5]ngml-1) and in the morning (85.5 [0-247.8]ngml-1) compared with controls (30.3 [0-176.8]ngml-1 and 36.3 [0-167.1]ngml-1, evening and morning, respectively, both p<0.05). On the contrary, C5a and SC5b-9 levels were comparable between patients and controls at each time point (p>0.05). There was no change in complement factors from evening to morning in either group (p>0.05), except for C5a that decreased from evening to morning in obstructive sleep apnea (from 11.6 [1.6-47.4]ngml-1 to 9.3 [0-46.4]ngml-1, p=0.01). Elevated C3a levels were directly related to obstructive sleep apnea severity, and were significantly associated with male gender, weight, body mass index, hypertension, high C-reactive protein and low high-density lipoprotein cholesterol (p<0.05). The complement system is activated in obstructive sleep apnea, which is correlated with disease severity. Our findings highlight the potential role of complement system in the pathophysiology of obstructive sleep apnea, thus facilitating further research.

Original languageEnglish
JournalJournal of Sleep Research
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Complement Activation
Obstructive Sleep Apnea
C-Reactive Protein
LDL Cholesterol
HDL Cholesterol
Blood Proteins
Complement System Proteins
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Hypertension
Inflammation
Weights and Measures
Research

Keywords

  • Apnea
  • Co-morbidities
  • Inflammation
  • Sleep

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Horváth, P., Tarnoki, D. L., Tarnoki, A. D., Karlinger, K., Lazar, Z., Losonczy, G., ... Bikov, A. (Accepted/In press). Complement system activation in obstructive sleep apnea. Journal of Sleep Research. https://doi.org/10.1111/jsr.12674

Complement system activation in obstructive sleep apnea. / Horváth, P.; Tarnoki, David L.; Tarnoki, Adam D.; Karlinger, K.; Lazar, Zsofia; Losonczy, Gyorgy; Kunos, Laszlo; Bikov, Andras.

In: Journal of Sleep Research, 01.01.2018.

Research output: Contribution to journalArticle

Horváth, P. ; Tarnoki, David L. ; Tarnoki, Adam D. ; Karlinger, K. ; Lazar, Zsofia ; Losonczy, Gyorgy ; Kunos, Laszlo ; Bikov, Andras. / Complement system activation in obstructive sleep apnea. In: Journal of Sleep Research. 2018.
@article{d0f6f52b19474ed0982afeeb22eb8d05,
title = "Complement system activation in obstructive sleep apnea",
abstract = "The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study the involvement of effector complement elements in obstructive sleep apnea, namely C3a, C5a and SC5b-9. Venous blood was collected in 50 patients with obstructive sleep apnea and 26 control subjects in the evening and the following morning. Plasma complement proteins were analysed with ELISA. Complement factor levels were compared between the two groups and correlated with clinical variables. Plasma C3a concentration was elevated in obstructive sleep apnea both in the evening (84.1 [0-338.5]ngml-1) and in the morning (85.5 [0-247.8]ngml-1) compared with controls (30.3 [0-176.8]ngml-1 and 36.3 [0-167.1]ngml-1, evening and morning, respectively, both p<0.05). On the contrary, C5a and SC5b-9 levels were comparable between patients and controls at each time point (p>0.05). There was no change in complement factors from evening to morning in either group (p>0.05), except for C5a that decreased from evening to morning in obstructive sleep apnea (from 11.6 [1.6-47.4]ngml-1 to 9.3 [0-46.4]ngml-1, p=0.01). Elevated C3a levels were directly related to obstructive sleep apnea severity, and were significantly associated with male gender, weight, body mass index, hypertension, high C-reactive protein and low high-density lipoprotein cholesterol (p<0.05). The complement system is activated in obstructive sleep apnea, which is correlated with disease severity. Our findings highlight the potential role of complement system in the pathophysiology of obstructive sleep apnea, thus facilitating further research.",
keywords = "Apnea, Co-morbidities, Inflammation, Sleep",
author = "P. Horv{\'a}th and Tarnoki, {David L.} and Tarnoki, {Adam D.} and K. Karlinger and Zsofia Lazar and Gyorgy Losonczy and Laszlo Kunos and Andras Bikov",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/jsr.12674",
language = "English",
journal = "Journal of Sleep Research",
issn = "0962-1105",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Complement system activation in obstructive sleep apnea

AU - Horváth, P.

AU - Tarnoki, David L.

AU - Tarnoki, Adam D.

AU - Karlinger, K.

AU - Lazar, Zsofia

AU - Losonczy, Gyorgy

AU - Kunos, Laszlo

AU - Bikov, Andras

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study the involvement of effector complement elements in obstructive sleep apnea, namely C3a, C5a and SC5b-9. Venous blood was collected in 50 patients with obstructive sleep apnea and 26 control subjects in the evening and the following morning. Plasma complement proteins were analysed with ELISA. Complement factor levels were compared between the two groups and correlated with clinical variables. Plasma C3a concentration was elevated in obstructive sleep apnea both in the evening (84.1 [0-338.5]ngml-1) and in the morning (85.5 [0-247.8]ngml-1) compared with controls (30.3 [0-176.8]ngml-1 and 36.3 [0-167.1]ngml-1, evening and morning, respectively, both p<0.05). On the contrary, C5a and SC5b-9 levels were comparable between patients and controls at each time point (p>0.05). There was no change in complement factors from evening to morning in either group (p>0.05), except for C5a that decreased from evening to morning in obstructive sleep apnea (from 11.6 [1.6-47.4]ngml-1 to 9.3 [0-46.4]ngml-1, p=0.01). Elevated C3a levels were directly related to obstructive sleep apnea severity, and were significantly associated with male gender, weight, body mass index, hypertension, high C-reactive protein and low high-density lipoprotein cholesterol (p<0.05). The complement system is activated in obstructive sleep apnea, which is correlated with disease severity. Our findings highlight the potential role of complement system in the pathophysiology of obstructive sleep apnea, thus facilitating further research.

AB - The complement system may play a role in the systemic inflammation characterising obstructive sleep apnea; however, this has not been investigated before. We aimed to study the involvement of effector complement elements in obstructive sleep apnea, namely C3a, C5a and SC5b-9. Venous blood was collected in 50 patients with obstructive sleep apnea and 26 control subjects in the evening and the following morning. Plasma complement proteins were analysed with ELISA. Complement factor levels were compared between the two groups and correlated with clinical variables. Plasma C3a concentration was elevated in obstructive sleep apnea both in the evening (84.1 [0-338.5]ngml-1) and in the morning (85.5 [0-247.8]ngml-1) compared with controls (30.3 [0-176.8]ngml-1 and 36.3 [0-167.1]ngml-1, evening and morning, respectively, both p<0.05). On the contrary, C5a and SC5b-9 levels were comparable between patients and controls at each time point (p>0.05). There was no change in complement factors from evening to morning in either group (p>0.05), except for C5a that decreased from evening to morning in obstructive sleep apnea (from 11.6 [1.6-47.4]ngml-1 to 9.3 [0-46.4]ngml-1, p=0.01). Elevated C3a levels were directly related to obstructive sleep apnea severity, and were significantly associated with male gender, weight, body mass index, hypertension, high C-reactive protein and low high-density lipoprotein cholesterol (p<0.05). The complement system is activated in obstructive sleep apnea, which is correlated with disease severity. Our findings highlight the potential role of complement system in the pathophysiology of obstructive sleep apnea, thus facilitating further research.

KW - Apnea

KW - Co-morbidities

KW - Inflammation

KW - Sleep

UR - http://www.scopus.com/inward/record.url?scp=85042564341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042564341&partnerID=8YFLogxK

U2 - 10.1111/jsr.12674

DO - 10.1111/jsr.12674

M3 - Article

C2 - 29493039

AN - SCOPUS:85042564341

JO - Journal of Sleep Research

JF - Journal of Sleep Research

SN - 0962-1105

ER -