Complement synthesis influencing factors produced by acute myeloid leukemia blast cells

Béla Schmidt, Márta Válay, Sarolta Nahajevszky, Ervin Pitlik, G. Füst

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In a previous study, we found hypercomplementaemia in the sera of acute myeloid leukemia patients. In this study we show that the supernatants of mononuclear cells, derived from peripheral blood taken in the blastic phase, from patients with acute myeloid leukemia (CM-AML) increased the in vitro complement protein synthesis of HepG2 hepatocellular carcinoma cells. This effect of CM-AML was mediated by heat labile soluble factors and involved the synthesis of mRNA and protein. Inhibition experiments with anti-cytokine antibodies and immunoaffinity chromatography revealed that this effect of CM-AML is mostly mediated by IL-1 and IL-6.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalPathology and Oncology Research
Volume1
Issue number1
DOIs
Publication statusPublished - Mar 1995

Fingerprint

Acute Myeloid Leukemia
Interleukin-1
Chromatography
Anti-Idiotypic Antibodies
Hepatocellular Carcinoma
Interleukin-6
Complement System Proteins
Hot Temperature
Cytokines
Messenger RNA
Serum
Proteins
In Vitro Techniques

Keywords

  • AML
  • C3
  • C4
  • Cl-INH
  • complement factor B
  • IL-2
  • IL-6
  • IL-lb
  • TNF

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Complement synthesis influencing factors produced by acute myeloid leukemia blast cells. / Schmidt, Béla; Válay, Márta; Nahajevszky, Sarolta; Pitlik, Ervin; Füst, G.

In: Pathology and Oncology Research, Vol. 1, No. 1, 03.1995, p. 54-59.

Research output: Contribution to journalArticle

Schmidt, Béla ; Válay, Márta ; Nahajevszky, Sarolta ; Pitlik, Ervin ; Füst, G. / Complement synthesis influencing factors produced by acute myeloid leukemia blast cells. In: Pathology and Oncology Research. 1995 ; Vol. 1, No. 1. pp. 54-59.
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