Complement activation in the nasal mucosa following nasal ragweed-allergen challenge

Györgyi Mezei, Lilian Varga, Amarilla Veres, George Füst, Endre Cserháti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to explore complement activation in the nasal lavage following a nasal ragweed-allergen challenge. The study was carried out with 15 adolescents who were allergic to ragweed and with six non-allergic healthy volunteers. Following the baseline measurement after the symptoms were registered, subjects were given increasing doses of ragweed allergen. Lavage fluid was collected and tested for a complement-activation product (C3bBbP). The allergic patients responded to allergen provocation with an increase in C3bBbP formation compared to the initial lavage (p=0.001). The C3bBbP level remained low in the lavage fluids of the non-allergic controls. We found a strong correlation between the threshold dose that induced symptoms and the dose where the maximum complement activation was detected (r=0.78, p=0.001). Our findings indicate that in allergic patients nasal challenge with ragweed allergen induces a rise in complement activation in the nasal lavage fluid. These results highlight the role of the complement system in the allergic inflammation on the nasal mucosal surface.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalPediatric Allergy and Immunology
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 31 2001

Keywords

  • Complement activation
  • Nasal challenge
  • Nasal lavage fluid
  • Ragweed allergy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

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