Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma membranes

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Abstract

Interaction of primycin antibiotic with oleic acid was investigated to understand the effect of primycin on lipid membranes at a molecular level. The thermodynamic parameters of the complex formation were determined by photoluminescence studies. Results highlight the presence of two interactions between the interacted species according to the cases in which one or two hydrogen bonds stabilize the molecular complexes. Although both interactions result in similar Gibbs-free enthalpy change at room temperature, the enthalpy and entropy changes associated with the formation of single or double hydrogen bonds are quite different. Quantum chemical and anisotropy decay studies validated that the formation of a single or double hydrogen bond between these species is driven by entropy in the former or enthalpy in the latter case. Owing to the resultant quite different temperature dependence of these two interactions, after detailed examinations in a cellular environment, this property could have importance in application of primycin on differently fevered bodies.

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalJournal of Antibiotics
Volume63
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Oleic Acid
Hydrogen
Cell Membrane
Entropy
Anti-Bacterial Agents
Temperature
Anisotropy
Membrane Lipids
Thermodynamics
primycin

Keywords

  • Antimycotic
  • Interactions
  • Membrane
  • Oleic acid
  • Primycin

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

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abstract = "Interaction of primycin antibiotic with oleic acid was investigated to understand the effect of primycin on lipid membranes at a molecular level. The thermodynamic parameters of the complex formation were determined by photoluminescence studies. Results highlight the presence of two interactions between the interacted species according to the cases in which one or two hydrogen bonds stabilize the molecular complexes. Although both interactions result in similar Gibbs-free enthalpy change at room temperature, the enthalpy and entropy changes associated with the formation of single or double hydrogen bonds are quite different. Quantum chemical and anisotropy decay studies validated that the formation of a single or double hydrogen bond between these species is driven by entropy in the former or enthalpy in the latter case. Owing to the resultant quite different temperature dependence of these two interactions, after detailed examinations in a cellular environment, this property could have importance in application of primycin on differently fevered bodies.",
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T1 - Competitive hydrogen bonds associated with the effect of primycin antibiotic on oleic acid as a building block of plasma membranes

AU - Virág, Eszter

AU - Pesti, M.

AU - Kunsági-Máté, S.

PY - 2010/3

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N2 - Interaction of primycin antibiotic with oleic acid was investigated to understand the effect of primycin on lipid membranes at a molecular level. The thermodynamic parameters of the complex formation were determined by photoluminescence studies. Results highlight the presence of two interactions between the interacted species according to the cases in which one or two hydrogen bonds stabilize the molecular complexes. Although both interactions result in similar Gibbs-free enthalpy change at room temperature, the enthalpy and entropy changes associated with the formation of single or double hydrogen bonds are quite different. Quantum chemical and anisotropy decay studies validated that the formation of a single or double hydrogen bond between these species is driven by entropy in the former or enthalpy in the latter case. Owing to the resultant quite different temperature dependence of these two interactions, after detailed examinations in a cellular environment, this property could have importance in application of primycin on differently fevered bodies.

AB - Interaction of primycin antibiotic with oleic acid was investigated to understand the effect of primycin on lipid membranes at a molecular level. The thermodynamic parameters of the complex formation were determined by photoluminescence studies. Results highlight the presence of two interactions between the interacted species according to the cases in which one or two hydrogen bonds stabilize the molecular complexes. Although both interactions result in similar Gibbs-free enthalpy change at room temperature, the enthalpy and entropy changes associated with the formation of single or double hydrogen bonds are quite different. Quantum chemical and anisotropy decay studies validated that the formation of a single or double hydrogen bond between these species is driven by entropy in the former or enthalpy in the latter case. Owing to the resultant quite different temperature dependence of these two interactions, after detailed examinations in a cellular environment, this property could have importance in application of primycin on differently fevered bodies.

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