Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods

Z. Aigner, R. Heinrich, E. Sipos, G. Farkas, A. Ciurba, O. Berkesi, P. Szabó-Révész

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The compatibility of aceclofenac with various tableting excipients was investigated by means of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The excipients applied in the direct pressing retard tablets were Carbopol 940, hydroxypropyl-methyl-cellulose, microcrystalline cellulose, Aerosil 200 and magnesium stearate. The ingredients alone and their 1:1 (w/w) binary mixtures were investigated before and after accelerated storage. An interaction was observed only between aceclofenac and magnesium stearate. The DSC and FT-IR examinations indicated formation of the magnesium salt of aceclofenac. For the other mixtures, there was no incompatibility between the components.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalJournal of Thermal Analysis and Calorimetry
Volume104
Issue number1
DOIs
Publication statusPublished - Apr 1 2011

Keywords

  • Aceclofenac
  • Compatibility
  • DSC
  • FT-IR
  • Magnesium stearate

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Fingerprint Dive into the research topics of 'Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods'. Together they form a unique fingerprint.

  • Cite this