Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods

Z. Aigner, R. Heinrich, E. Sipos, G. Farkas, A. Ciurba, O. Berkesi, P. Szabó-Révész

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The compatibility of aceclofenac with various tableting excipients was investigated by means of differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The excipients applied in the direct pressing retard tablets were Carbopol 940, hydroxypropyl-methyl-cellulose, microcrystalline cellulose, Aerosil 200 and magnesium stearate. The ingredients alone and their 1:1 (w/w) binary mixtures were investigated before and after accelerated storage. An interaction was observed only between aceclofenac and magnesium stearate. The DSC and FT-IR examinations indicated formation of the magnesium salt of aceclofenac. For the other mixtures, there was no incompatibility between the components.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalJournal of Thermal Analysis and Calorimetry
Volume104
Issue number1
DOIs
Publication statusPublished - Apr 2011

Fingerprint

tablets
Excipients
compatibility
Tablets
magnesium
stearates
carbopol 940
infrared spectroscopy
cellulose
Differential scanning calorimetry
heat measurement
incompatibility
scanning
pressing
Binary mixtures
ingredients
Silicon Dioxide
Magnesium
binary mixtures
Salts

Keywords

  • Aceclofenac
  • Compatibility
  • DSC
  • FT-IR
  • Magnesium stearate

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FT-IR spectroscopic methods. / Aigner, Z.; Heinrich, R.; Sipos, E.; Farkas, G.; Ciurba, A.; Berkesi, O.; Szabó-Révész, P.

In: Journal of Thermal Analysis and Calorimetry, Vol. 104, No. 1, 04.2011, p. 265-271.

Research output: Contribution to journalArticle

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AU - Berkesi, O.

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