Compartment-specific tyrosine hydroxylase-positive innervation to AII amacrine cells in the rabbit retina

B. Völgyi, G. Debertin, M. Balogh, E. Popovich, T. Kovács-Öller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Tyrosine-hydroxylase-positive (TH+) amacrine cells release dopamine in a paracrine manner and also form GABA-ergic contact sites with inner retinal neurons. The best known sites are formed by TH+ fibrous rings and AII amacrine cell somata in stratum 1 of the inner plexiform layer (IPL). An AII amacrine cell is a highly compartmentalized neuron with relatively large soma, a stout dendritic stalk and two sets of processes, one showing lobular appearance and extending horizontally in stratum 1 and a second transversally elongated group of fibers in strata 4 and 5. Although, all of these compartments have been reported as tic sites, it is uncertain if TH+ amacrine cell inputs are homogeneously distributed or they rather target specific AII cell compartments. In this study we investigated the TH+/AII cell system by immunohistochemistry to map the potential synaptic contacts in the rabbit retina. We found numerous intimate contacts between the two amacrine cell populations throughout the IPL. However, TH+ fibers favored the soma/main stalk region of AII amacrine cells and only contacted lobular appendages and transversal processes sporadically. In addition to the well-studied contacts between AII cell somata and TH+ rings in stratum 1 we found that the main stalk region in stratum 3 serves as a secondary major target for TH+ axons. These data thus clearly show that TH+ contacts to AII amacrine cells are highly compartment specific.

Original languageEnglish
Pages (from-to)88-97
Number of pages10
JournalNeuroscience
Volume270
DOIs
Publication statusPublished - Jun 13 2014

Fingerprint

Amacrine Cells
Tyrosine 3-Monooxygenase
Retina
Rabbits
Carisoprodol
Retinal Neurons
Tics
Synaptic Potentials
gamma-Aminobutyric Acid
Axons
Dopamine
Immunohistochemistry
Neurons
Population

Keywords

  • Amacrine cell
  • Dopamine
  • Parvalbumin
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Compartment-specific tyrosine hydroxylase-positive innervation to AII amacrine cells in the rabbit retina. / Völgyi, B.; Debertin, G.; Balogh, M.; Popovich, E.; Kovács-Öller, T.

In: Neuroscience, Vol. 270, 13.06.2014, p. 88-97.

Research output: Contribution to journalArticle

Völgyi, B. ; Debertin, G. ; Balogh, M. ; Popovich, E. ; Kovács-Öller, T. / Compartment-specific tyrosine hydroxylase-positive innervation to AII amacrine cells in the rabbit retina. In: Neuroscience. 2014 ; Vol. 270. pp. 88-97.
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