A Helicobacter pylori-fertózést kimutató eljárások összehasonlítása.

Translated title of the contribution: Comparison of various methods in the detection of Helicobacter pylori infection

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There are several possible methods to detect H. pylori in the gastric mucosa. The aim of our prospective study was to evaluate the diagnostic value of these tests and to define their place in the clinical practice. 109 (45 male, 64 female) patients who underwent upper GI endoscopy were included. Before endoscopy, whole blood was collected for serological test and 13C-UBT (13C-urea breath test) was performed. During endoscopy, multiple biopsies were collected from the antrum and corpus for the examination of H. pylori status by histology and rapid urease test. Patients with positive histology and a positive result of any other examinations, or--in case of negative histology--with two positive results of the remaining examinations were considered to be H. pylori-positive. 50 patients (46%) proved to be H. pylori-positive. Sensitivity and specificity, respectively, were as follows [in brackets: negative predictive value (NPV) and positive predictive value (PPV), respectively]: histology, 98% and 92% (98% and 91%); 13C-UBT, 93% and 98% (94% and 98%); rapid urease test, 83% and 100% (86% and 100%); serological examination, 86% and 74% (88% and 70%). The sensitivity and the clinical role of the methods used for the detection of H, pylori infection is different. Histology is the most reliable method if endoscopy in performed. The positive result of the rapid urease test is also of good diagnostic value. The 13C-UBT is the method of choice if no endoscopy is performed and the clarification of H. pylori status is necessary. This method can be useful to control the success of bacterium eradication as well. The serological examination provides instant result, therefore this method is proposed for screening and epidemiological studies.

Original languageHungarian
Pages (from-to)911-914
Number of pages4
JournalOrvosi Hetilap
Volume141
Issue number17
Publication statusPublished - Apr 23 2000

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Helicobacter Infections
Helicobacter pylori
Endoscopy
Histology
Breath Tests
Urease
Urea
Pylorus
Serologic Tests
Gastric Mucosa
Routine Diagnostic Tests
Epidemiologic Studies
Prospective Studies
Bacteria
Biopsy
Sensitivity and Specificity
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A Helicobacter pylori-fertózést kimutató eljárások összehasonlítása. / Juhász, M.; Prónai, L.; Zágoni, T.; Németh, A.; Herszényi, L.; Schandl, L.; Tulassay, Z.

In: Orvosi Hetilap, Vol. 141, No. 17, 23.04.2000, p. 911-914.

Research output: Contribution to journalArticle

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abstract = "There are several possible methods to detect H. pylori in the gastric mucosa. The aim of our prospective study was to evaluate the diagnostic value of these tests and to define their place in the clinical practice. 109 (45 male, 64 female) patients who underwent upper GI endoscopy were included. Before endoscopy, whole blood was collected for serological test and 13C-UBT (13C-urea breath test) was performed. During endoscopy, multiple biopsies were collected from the antrum and corpus for the examination of H. pylori status by histology and rapid urease test. Patients with positive histology and a positive result of any other examinations, or--in case of negative histology--with two positive results of the remaining examinations were considered to be H. pylori-positive. 50 patients (46{\%}) proved to be H. pylori-positive. Sensitivity and specificity, respectively, were as follows [in brackets: negative predictive value (NPV) and positive predictive value (PPV), respectively]: histology, 98{\%} and 92{\%} (98{\%} and 91{\%}); 13C-UBT, 93{\%} and 98{\%} (94{\%} and 98{\%}); rapid urease test, 83{\%} and 100{\%} (86{\%} and 100{\%}); serological examination, 86{\%} and 74{\%} (88{\%} and 70{\%}). The sensitivity and the clinical role of the methods used for the detection of H, pylori infection is different. Histology is the most reliable method if endoscopy in performed. The positive result of the rapid urease test is also of good diagnostic value. The 13C-UBT is the method of choice if no endoscopy is performed and the clarification of H. pylori status is necessary. This method can be useful to control the success of bacterium eradication as well. The serological examination provides instant result, therefore this method is proposed for screening and epidemiological studies.",
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AU - Tulassay, Z.

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