Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response

Mina Farag, Nikhil Prakash Patil, Anton Sabashnikov, Rawa Arif, G. Szabó, Klaus Kallenbach, Arjang Ruhparwar, Matthias Karck, Thorsten Brenner, Stefan Hofer, Alexander Weymann

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cardiopulmonary bypass (CPB) is a known mediator of systemic inflammatory response. Extracorporeal circulations are undergoing continuous modifications and optimizations to achieve better results. Hence we aim to compare the inflammatory response associated with two recent miniature extracorporeal circulation systems during normothermic CPB. We measured plasma levels of cytokines including interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor-α, migration inhibitory factor (MIF), receptor for advanced glycation endproduct, and cluster of differentiation 40 ligand in 60 consecutive patients during the first 24 h after CPB. The patients were prospectively randomized to one of three trial groups: patients in group A were operated with the minimal extracorporeal circulation circuit (MECC, Maquet, Rastatt, Germany), group B operated with the extracorporeal circulation circuit optimized (ECC.O, Sorin, Italy), and group C operated with a conventional extracorporeal circuit (CECC, Maquet). Arterial blood samples were collected at intervals before, 30 min after initiation, and after termination of CPB. Further samples were collected 6 and 24 h after CPB. IL-10 levels were significantly raised in the CECC group as compared with either of the mini ECC-circuits with a peak concentration at 6 h postoperatively. Human MIF concentrations were significantly higher in the CECC group starting 30 min after CPB and peaking at the end of CPB. The overall reduction in cytokine concentrations in the mini-ECC groups correlated with a lower need for blood transfusion in MECC and a shorter mechanical ventilation time for ECC.O. Normothermic CPB using minimally invasive extracorporeal circulation circuits can reduce the inflammatory response as measured by cytokine levels, which may be beneficial for perioperative preservation of pulmonary function and hemostasis in low risk patients.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalArtificial Organs
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Cardiopulmonary Bypass
Extracorporeal Circulation
Networks (circuits)
Cytokines
Interleukin-10
Micellar Electrokinetic Capillary Chromatography
Blood
Interleukin-1
Human Migration
Interleukin-6
Tumor Necrosis Factor-alpha
Ligands
Plasmas
Hemostasis
Artificial Respiration
Blood Transfusion
Italy
Germany
Lung

Keywords

  • Coronary artery bypass grafting
  • Cytokine release
  • Inflammatory response
  • Miniaturized extracorporeal circulation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Farag, M., Patil, N. P., Sabashnikov, A., Arif, R., Szabó, G., Kallenbach, K., ... Weymann, A. (2017). Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response. Artificial Organs, 41(2), 139-145. https://doi.org/10.1111/aor.12750

Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response. / Farag, Mina; Patil, Nikhil Prakash; Sabashnikov, Anton; Arif, Rawa; Szabó, G.; Kallenbach, Klaus; Ruhparwar, Arjang; Karck, Matthias; Brenner, Thorsten; Hofer, Stefan; Weymann, Alexander.

In: Artificial Organs, Vol. 41, No. 2, 01.02.2017, p. 139-145.

Research output: Contribution to journalArticle

Farag, M, Patil, NP, Sabashnikov, A, Arif, R, Szabó, G, Kallenbach, K, Ruhparwar, A, Karck, M, Brenner, T, Hofer, S & Weymann, A 2017, 'Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response', Artificial Organs, vol. 41, no. 2, pp. 139-145. https://doi.org/10.1111/aor.12750
Farag, Mina ; Patil, Nikhil Prakash ; Sabashnikov, Anton ; Arif, Rawa ; Szabó, G. ; Kallenbach, Klaus ; Ruhparwar, Arjang ; Karck, Matthias ; Brenner, Thorsten ; Hofer, Stefan ; Weymann, Alexander. / Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response. In: Artificial Organs. 2017 ; Vol. 41, No. 2. pp. 139-145.
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