Imipramin-xilazin gyógyszeres kombinációjával ménektol vett sperma összehasonlítása a hagyományos úton vett ejakulátummal

Translated title of the contribution: Comparison of the results of pharmacologically induced imipramine-xylazine and in copula ejaculation in stallions

Horváth András, Veres Kata Orsolya, Szenci Ottó, John Vasarhelyi, Szegho Zsolt, Szoboszlai Henriett

Research output: Contribution to journalArticle

2 Citations (Scopus)


The possibility of an alternative, chemically (imipramine-xylazine combination) induced ejaculation method was studied in stallions. The advantage of this method is that it allows to collect semen from stallions, which are genetically valuable, or have an impressive sport performance, but they are not able to service mares naturally due to suffering from physical (leg or spinal) or psychic (ejaculatory dysfunction) problems. Initially, semen was collected three to four times from each of the four stallions, using the traditional "artificial vagina" method, to serve as controls. After this, induction of ejaculation in each of the stallions at six occasions was studied by administering imipramine orally and two hours later an intravenous dose of xylazine. In the first five trials the xylazine dose was constant (0.35 mg/bwkg), but the dosage of imipramine (2.5 mg/bwkg to 5 mg/bwkg) was increased gradually, while in the sixth trial 4 mg/bwkg impramine and 0.66 mg/bwkg xylazine were administrated. To minimise the disturbance of the stallions, all procedures were done in their own stalls. Despite their effort to find an optimum dose of combination for each of the stallions, only one of the 24 experiments resulted in an ejaculation. A macroscopic and a motility analysis using the CASA system (Computer Assisted Sperm Analyser) were performed in all cases, in order to compare the two methods. As expected, the chemically induced ejaculation showed a high concentration and a high total number of sperms. In contrast with the literature data only a low rate of success in the chemical induction of ejaculation was achieved, therefore imipramine-xylazine combination can not be recommended for the practice. Further studies are needed to evaluate the causal factors of the low rate success in their cases.

Original languageHungarian
Pages (from-to)451-458
Number of pages8
JournalMagyar Allatorvosok Lapja
Issue number8
Publication statusPublished - Aug 1 2004


ASJC Scopus subject areas

  • veterinary(all)

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