Comparison of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations after first-line treatment in Hodgkin's lymphoma

Kornélia Kajáry, Zsuzsa Molnár, Tamás Györke, S. Szakáll, P. Molnár, Z. Lengyel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE: Fluorine 18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) has been reported to have a wide-ranging positive predictive value (PPV) in the literary data on Hodgkin's lymphoma after first-line therapy. This study was carried out to compare the usefulness of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations for this indication. METHODS: Data from 66 patients with a median follow-up care of 54 months were evaluated. The initial stage had been I-II in the case of 45 patients and III-IV in the case of 21 patients. RESULTS: The analysis based on the International Harmonization Project criteria resulted in a negative predictive value (NPV) of 98.0% and a PPV of 62.5%. Using mediastinal blood pool and liver activity as the thresholds for the London criteria, the NPV and PPV were 98.0 and 62.5% and 98.1 and 71.4%, respectively. Considering only those lesions with 18F-FDG uptake that was markedly higher than liver uptake as positive, the NPV and PPV were 94.7 and 88.9%, respectively. The analysis based on the Gallamini criteria resulted in an NPV of 96.2% and a PPV of 69.2%. CONCLUSION: Using the London criteria with liver activity as the threshold seems to be a good approach for the interpretation of post-treatment 18F-FDG PET/CT studies because of its high accuracy and simplicity.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalNuclear Medicine Communications
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2014

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Fluorodeoxyglucose F18
Hodgkin Disease
Tomography
Liver
Therapeutics
Aftercare

Keywords

  • Gallamini criteria
  • Hodgkin's lymphoma
  • International Harmonization Project
  • London criteria
  • post-treatment F-FDG PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{593a9f3fa8d548c5ac92a94db1a94241,
title = "Comparison of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations after first-line treatment in Hodgkin's lymphoma",
abstract = "OBJECTIVE: Fluorine 18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) has been reported to have a wide-ranging positive predictive value (PPV) in the literary data on Hodgkin's lymphoma after first-line therapy. This study was carried out to compare the usefulness of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations for this indication. METHODS: Data from 66 patients with a median follow-up care of 54 months were evaluated. The initial stage had been I-II in the case of 45 patients and III-IV in the case of 21 patients. RESULTS: The analysis based on the International Harmonization Project criteria resulted in a negative predictive value (NPV) of 98.0{\%} and a PPV of 62.5{\%}. Using mediastinal blood pool and liver activity as the thresholds for the London criteria, the NPV and PPV were 98.0 and 62.5{\%} and 98.1 and 71.4{\%}, respectively. Considering only those lesions with 18F-FDG uptake that was markedly higher than liver uptake as positive, the NPV and PPV were 94.7 and 88.9{\%}, respectively. The analysis based on the Gallamini criteria resulted in an NPV of 96.2{\%} and a PPV of 69.2{\%}. CONCLUSION: Using the London criteria with liver activity as the threshold seems to be a good approach for the interpretation of post-treatment 18F-FDG PET/CT studies because of its high accuracy and simplicity.",
keywords = "Gallamini criteria, Hodgkin's lymphoma, International Harmonization Project, London criteria, post-treatment F-FDG PET/CT",
author = "Korn{\'e}lia Kaj{\'a}ry and Zsuzsa Moln{\'a}r and Tam{\'a}s Gy{\"o}rke and S. Szak{\'a}ll and P. Moln{\'a}r and Z. Lengyel",
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doi = "10.1097/MNM.0000000000000024",
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pages = "169--175",
journal = "Nuclear Medicine Communications",
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T1 - Comparison of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations after first-line treatment in Hodgkin's lymphoma

AU - Kajáry, Kornélia

AU - Molnár, Zsuzsa

AU - Györke, Tamás

AU - Szakáll, S.

AU - Molnár, P.

AU - Lengyel, Z.

PY - 2014/2

Y1 - 2014/2

N2 - OBJECTIVE: Fluorine 18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) has been reported to have a wide-ranging positive predictive value (PPV) in the literary data on Hodgkin's lymphoma after first-line therapy. This study was carried out to compare the usefulness of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations for this indication. METHODS: Data from 66 patients with a median follow-up care of 54 months were evaluated. The initial stage had been I-II in the case of 45 patients and III-IV in the case of 21 patients. RESULTS: The analysis based on the International Harmonization Project criteria resulted in a negative predictive value (NPV) of 98.0% and a PPV of 62.5%. Using mediastinal blood pool and liver activity as the thresholds for the London criteria, the NPV and PPV were 98.0 and 62.5% and 98.1 and 71.4%, respectively. Considering only those lesions with 18F-FDG uptake that was markedly higher than liver uptake as positive, the NPV and PPV were 94.7 and 88.9%, respectively. The analysis based on the Gallamini criteria resulted in an NPV of 96.2% and a PPV of 69.2%. CONCLUSION: Using the London criteria with liver activity as the threshold seems to be a good approach for the interpretation of post-treatment 18F-FDG PET/CT studies because of its high accuracy and simplicity.

AB - OBJECTIVE: Fluorine 18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) has been reported to have a wide-ranging positive predictive value (PPV) in the literary data on Hodgkin's lymphoma after first-line therapy. This study was carried out to compare the usefulness of the International Harmonization Project, London and Gallamini criteria in the interpretation of 18F-FDG PET/CT examinations for this indication. METHODS: Data from 66 patients with a median follow-up care of 54 months were evaluated. The initial stage had been I-II in the case of 45 patients and III-IV in the case of 21 patients. RESULTS: The analysis based on the International Harmonization Project criteria resulted in a negative predictive value (NPV) of 98.0% and a PPV of 62.5%. Using mediastinal blood pool and liver activity as the thresholds for the London criteria, the NPV and PPV were 98.0 and 62.5% and 98.1 and 71.4%, respectively. Considering only those lesions with 18F-FDG uptake that was markedly higher than liver uptake as positive, the NPV and PPV were 94.7 and 88.9%, respectively. The analysis based on the Gallamini criteria resulted in an NPV of 96.2% and a PPV of 69.2%. CONCLUSION: Using the London criteria with liver activity as the threshold seems to be a good approach for the interpretation of post-treatment 18F-FDG PET/CT studies because of its high accuracy and simplicity.

KW - Gallamini criteria

KW - Hodgkin's lymphoma

KW - International Harmonization Project

KW - London criteria

KW - post-treatment F-FDG PET/CT

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