Comparison of the electromechanical effects of vesnarinone and amrinone in isolated dog Purkinje strands and ventricular trabeculae

David A. Lathrop, Péter P. Náinási, A. Varró, Arnold Schwartz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 μM) and amrinone (1 μM-1 mm) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. Methods and Results: Both drugs increased contractility of trabecular muscle preparations, while, in Purkinje strands, vesnarinone failed to increase developed force during continuous pacing at 2 Hz. Vesnarinone lengthened APD in both preparations; although this effect was more marked in Purkinje strands. Ventricular muscle APD was not affected by amrinone (1 μM to 1 mM), while, in Purkinje strands, amrinone produced a biphasic effect on APD. Low concentrations (1-100 μM) of amrinone shortened Purkinje fiber APD, while only the highest concentration (1 mM) used lengthened APD. In addition, in Purkinje strand preparations the effects of vesnarinone (10 μM) on APD and developed force were proportional to pacing cycle length at frequencies slower than 2 Hz; however, at frequencies faster than 2 Hz vesnarinone decreased developed force while APD was lengthened. In ventricular trabecular muscle preparations, the effects of vesnarinone were not affected by frequency. Conclusions: These results indicate clear differences between the effects of vesnarinone and amrinone in isolated cardiac preparations. These differences in experimental effects in isolated cardiac preparations may help provide an explanation for the disappointing clinical response of patients in heart failure to amrinone, while vesnarinone has appeared to be beneficial.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume1
Issue number2
DOIs
Publication statusPublished - 1996

Fingerprint

Amrinone
Action Potentials
Dogs
Muscles
Purkinje Fibers
vesnarinone
Microelectrodes
Heart Failure

Keywords

  • Action potential duration
  • Amrinone
  • Force development
  • Phosphodiesterase inhibitors
  • Positive inotropy
  • Vesnarinone

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of the electromechanical effects of vesnarinone and amrinone in isolated dog Purkinje strands and ventricular trabeculae. / Lathrop, David A.; Náinási, Péter P.; Varró, A.; Schwartz, Arnold.

In: Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 1, No. 2, 1996, p. 133-140.

Research output: Contribution to journalArticle

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