Comparison of the effects of restacorin and flecainide on various cardiac transmembrane potassium currents

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2 Citations (Scopus)

Abstract

The effect of restacorin (5 μM) and flecainide (5 μM) on the transmembrane ionic currents was compared in dog and rabbit ventricular muscle by applying the conventional microelectrode and patch-clamp techniques. Neither restacorin nor flecainide influenced significantly the ATP-sensitive and inward rectifier potassium currents. Flecainide moderately decreased the amplitude of the transient outward current while restacorin did not change this current. The delayed rectifier potassium current was depressed markedly by flecainide and moderately by restacorin. These results suggest that although flecainide and restacorin cause similar changes in the various transmembrane ionic currents, there are some differences between the effects of the two antiarrhythmic compounds.

Original languageEnglish
Pages (from-to)317-318
Number of pages2
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

Fingerprint

Flecainide
Potassium
Microelectrodes
Patch-Clamp Techniques
Adenosine Triphosphate
restacorin
Dogs
Rabbits
Muscles

Keywords

  • Antiarrhythmic drugs
  • Flecainide
  • Potassium currents
  • Restacorin

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "The effect of restacorin (5 μM) and flecainide (5 μM) on the transmembrane ionic currents was compared in dog and rabbit ventricular muscle by applying the conventional microelectrode and patch-clamp techniques. Neither restacorin nor flecainide influenced significantly the ATP-sensitive and inward rectifier potassium currents. Flecainide moderately decreased the amplitude of the transient outward current while restacorin did not change this current. The delayed rectifier potassium current was depressed markedly by flecainide and moderately by restacorin. These results suggest that although flecainide and restacorin cause similar changes in the various transmembrane ionic currents, there are some differences between the effects of the two antiarrhythmic compounds.",
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AU - Németh, M.

AU - Virág, L.

AU - Varró, A.

AU - Papp, J.

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AB - The effect of restacorin (5 μM) and flecainide (5 μM) on the transmembrane ionic currents was compared in dog and rabbit ventricular muscle by applying the conventional microelectrode and patch-clamp techniques. Neither restacorin nor flecainide influenced significantly the ATP-sensitive and inward rectifier potassium currents. Flecainide moderately decreased the amplitude of the transient outward current while restacorin did not change this current. The delayed rectifier potassium current was depressed markedly by flecainide and moderately by restacorin. These results suggest that although flecainide and restacorin cause similar changes in the various transmembrane ionic currents, there are some differences between the effects of the two antiarrhythmic compounds.

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