Comparison of the effects of different drying techniques on properties of granules and tablets made on a production scale

Ágota Hegedus, Klára Pintye-Hódi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The aims of this study were to compare the properties of granules prepared in a high-shear granulator and dried by using different methods (fluid-bed and microwave-vacuum drying) and to compare the properties of tablets pressed from such granules. Experiments on a production scale were performed with Collette Ultima Pro 600 single-pot processing equipment and a Glatt WSG 200 fluid-bed granulator and drier. The particles granulated in the traditional high-shear granulator and dried in a vacuum chamber had a higher porosity and higher bulk and tapped densities, as a consequence of the special characteristics of the drying process. They retained their spherical form, in contrast with the particles dried via the fluid-bed technology. The two types of granules required different compressing forces for tabletting.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume330
Issue number1-2
DOIs
Publication statusPublished - Feb 7 2007

Keywords

  • Bulk and tapped densities
  • Fluid-bed drier
  • Particle size distribution
  • Porosity
  • Production scale
  • SEM
  • Single-pot processing equipment

ASJC Scopus subject areas

  • Pharmaceutical Science

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