Comparison of the anti-Ro/SSA autoantibody profile between patients with primary and secondary Sjogren's syndrome

I. Gal, G. Lakos, M. Zeher

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To measure serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies in patients with primary and secondary Sjogren's syndrome. To examine if there is any connection between the disease and the subtype-spectrum of these antibodies. Methods: We measured serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies by ELISA, in the sera of patients with primary Sjogren's syndrome with or without extraglandular manifestations and with or without anti-La/SSB positivity and of patients with systemic lupus erythematosus/Sjogren's syndrome overlapping disease with or without anti-La/SSB positivity. Results: Differences of the distribution of the anti-Ro52-kD/SSA and the anti-Ro60-kD/SSA were found between the primary and secondary Sjogren's syndrome patients' groups; when Sjogren's syndrome is accompanied by systemic lupus erythematosus, the occurrence of anti-Ro60-kD/SSA autoantibodies is significantly higher than in primary Sjogren's syndrome. Conclusion: Our results suggest that there is a possible connection between the distribution of the subtypes of the anti-Ro/SSA autoantibodies and the disease type in primary/secondary Sjogren's syndrome.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalAutoimmunity
Volume32
Issue number2
Publication statusPublished - 2000

Fingerprint

Sjogren's Syndrome
Autoantibodies
Systemic Lupus Erythematosus
Serum
Enzyme-Linked Immunosorbent Assay
Antibodies

Keywords

  • 52-kD
  • 60-kD
  • Anti-La/SSB
  • Anti-Ro/SSA
  • Autoantibodies
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Comparison of the anti-Ro/SSA autoantibody profile between patients with primary and secondary Sjogren's syndrome. / Gal, I.; Lakos, G.; Zeher, M.

In: Autoimmunity, Vol. 32, No. 2, 2000, p. 89-92.

Research output: Contribution to journalArticle

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T1 - Comparison of the anti-Ro/SSA autoantibody profile between patients with primary and secondary Sjogren's syndrome

AU - Gal, I.

AU - Lakos, G.

AU - Zeher, M.

PY - 2000

Y1 - 2000

N2 - Objective: To measure serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies in patients with primary and secondary Sjogren's syndrome. To examine if there is any connection between the disease and the subtype-spectrum of these antibodies. Methods: We measured serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies by ELISA, in the sera of patients with primary Sjogren's syndrome with or without extraglandular manifestations and with or without anti-La/SSB positivity and of patients with systemic lupus erythematosus/Sjogren's syndrome overlapping disease with or without anti-La/SSB positivity. Results: Differences of the distribution of the anti-Ro52-kD/SSA and the anti-Ro60-kD/SSA were found between the primary and secondary Sjogren's syndrome patients' groups; when Sjogren's syndrome is accompanied by systemic lupus erythematosus, the occurrence of anti-Ro60-kD/SSA autoantibodies is significantly higher than in primary Sjogren's syndrome. Conclusion: Our results suggest that there is a possible connection between the distribution of the subtypes of the anti-Ro/SSA autoantibodies and the disease type in primary/secondary Sjogren's syndrome.

AB - Objective: To measure serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies in patients with primary and secondary Sjogren's syndrome. To examine if there is any connection between the disease and the subtype-spectrum of these antibodies. Methods: We measured serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies by ELISA, in the sera of patients with primary Sjogren's syndrome with or without extraglandular manifestations and with or without anti-La/SSB positivity and of patients with systemic lupus erythematosus/Sjogren's syndrome overlapping disease with or without anti-La/SSB positivity. Results: Differences of the distribution of the anti-Ro52-kD/SSA and the anti-Ro60-kD/SSA were found between the primary and secondary Sjogren's syndrome patients' groups; when Sjogren's syndrome is accompanied by systemic lupus erythematosus, the occurrence of anti-Ro60-kD/SSA autoantibodies is significantly higher than in primary Sjogren's syndrome. Conclusion: Our results suggest that there is a possible connection between the distribution of the subtypes of the anti-Ro/SSA autoantibodies and the disease type in primary/secondary Sjogren's syndrome.

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