Comparison of tacalcitol ointment with short-contact dithranol therapy in the treatment of psoriasis vulgaris: A randomized multicentre, open prospective study on efficacy and safety

Beatrix Farkas, A. Dobozy, A. Horváth, J. Hunyadi, I. Schneider

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A multicentre, randomized, open, prospective, parallel-group trial was carried out to compare the efficacy, tolerability and safety of topical treatment with tacalcitol ointment (4 μg/g, applied once daily) with that of short-contact dithranol therapy. The tolerability of tacalcitol was significantly (P = 0.002) better and its efficacy was slightly better. Tacalcitol proved to be less (P <0.001) irritant than dithranol and did not stain the skin or clothes. The results suggest that tacalcitol is more convenient to use in plaque-type psoriasis than dithranol and does not produce the side-effects of topical corticosteroids and tar, making the drug a first-line treatment for chronic plaque psoriasis.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalJournal of Dermatological Treatment
Volume10
Issue number2
Publication statusPublished - Jun 1999

Fingerprint

Anthralin
Ointments
Psoriasis
Prospective Studies
Safety
Tars
Clothing
Irritants
Therapeutics
Adrenal Cortex Hormones
Coloring Agents
Skin
1 alpha,24-dihydroxyvitamin D3
Pharmaceutical Preparations

Keywords

  • Dithranol
  • Psoriasis
  • Tacalcitol
  • Vitamin D

ASJC Scopus subject areas

  • Dermatology

Cite this

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abstract = "A multicentre, randomized, open, prospective, parallel-group trial was carried out to compare the efficacy, tolerability and safety of topical treatment with tacalcitol ointment (4 μg/g, applied once daily) with that of short-contact dithranol therapy. The tolerability of tacalcitol was significantly (P = 0.002) better and its efficacy was slightly better. Tacalcitol proved to be less (P <0.001) irritant than dithranol and did not stain the skin or clothes. The results suggest that tacalcitol is more convenient to use in plaque-type psoriasis than dithranol and does not produce the side-effects of topical corticosteroids and tar, making the drug a first-line treatment for chronic plaque psoriasis.",
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T1 - Comparison of tacalcitol ointment with short-contact dithranol therapy in the treatment of psoriasis vulgaris

T2 - A randomized multicentre, open prospective study on efficacy and safety

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AU - Dobozy, A.

AU - Horváth, A.

AU - Hunyadi, J.

AU - Schneider, I.

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