Comparison of tacalcitol ointment with short-contact dithranol therapy in the treatment of psoriasis vulgaris: A randomized multicentre, open prospective study on efficacy and safety

Beatrix Farkas, A. Dobozy, A. Horváth, J. Hunyadi, I. Schneider

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A multicentre, randomized, open, prospective, parallel-group trial was carried out to compare the efficacy, tolerability and safety of topical treatment with tacalcitol ointment (4 μg/g, applied once daily) with that of short-contact dithranol therapy. The tolerability of tacalcitol was significantly (P = 0.002) better and its efficacy was slightly better. Tacalcitol proved to be less (P < 0.001) irritant than dithranol and did not stain the skin or clothes. The results suggest that tacalcitol is more convenient to use in plaque-type psoriasis than dithranol and does not produce the side-effects of topical corticosteroids and tar, making the drug a first-line treatment for chronic plaque psoriasis.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalJournal of Dermatological Treatment
Volume10
Issue number2
DOIs
Publication statusPublished - Jun 1999

Keywords

  • Dithranol
  • Psoriasis
  • Tacalcitol
  • Vitamin D

ASJC Scopus subject areas

  • Dermatology

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