Comparison of 125I stereotactic brachytherapy and LINAC radiosurgery modalities based on physical dose distribution and radiobiological efficacy

Arpad Viola, T. Major, Jeno Julow

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The goal of this study was to make a comparison between stereotactic brachytherapy implants and linear accelerator-based radiosurgery of brain tumors with respect to physical dose distributions and radiobiological efficacy. Twenty-four treatment plans made for irradiation of brain tumors with low-dose-rate 125I brachytherapy and multiple-arc LINAC-based radiosurgery were analyzed. Using the dose-volume histograms and the linear-quadratic model, the brachytherapy doses were compared to the brachytherapy-equivalent LINAC radiosurgery doses with respect to the predicted late effects of radiation on normal brain tissue. To characterize the conformity and homogeneity of dose distributions, the conformal index, external volume index, and relative homogeneity index were calculated for each dose plan and the mean values were compared. The average tumor volume was 5.6 cm3 (range: 0.1-19.3 cm3). At low doses, the calculated radiobiological late effect on normal tissue was equivalent for external-beam and brachytherapy dose delivery. For brachytherapy at doses greater than 30 Gy, the calculated equivalent dose to normal tissues was less than for external-beam radiosurgery. However, the dose-calculated homogeneity was better for the LINAC radiosurgery, with a mean relative homogeneity index of 0.62 compared to the calculated value of 0.19 for the brachytherapy (P = 0.0002). These results are only predictions based on calculations concerning normal tissue tolerance. More data and research are needed to understand the clinical relevance of these findings.

Original languageEnglish
Pages (from-to)695-702
Number of pages8
JournalRadiation Research
Volume165
Issue number6
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Radiosurgery
Brachytherapy
dosage
homogeneity
Brain Neoplasms
brain
tumors
Radiation Effects
neoplasms
Tumor Burden
Linear Models
linear accelerators
histograms
Brain
Research
delivery
accelerators
arcs
irradiation
linear models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Comparison of 125I stereotactic brachytherapy and LINAC radiosurgery modalities based on physical dose distribution and radiobiological efficacy. / Viola, Arpad; Major, T.; Julow, Jeno.

In: Radiation Research, Vol. 165, No. 6, 06.2006, p. 695-702.

Research output: Contribution to journalArticle

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