Comparison of structure, logP and P388 cytotoxicity of some phenyl and ferrocenyl cyclic chalcone analogues. Application of RP-TLC for logP determination of the ferrocenyl analogues

Pál Perjési, Krisztina Takács-Novák, Zsuzsanna Rozmer, Pál Sohár, Richard E. Bozak, Theresa M. Allen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cyclic chalcone analogues (2-5) and their ferrocenyl counterparts (6-10) were synthesized and their logP and P388 cyctotoxity were investigated. The structures of the newly synthesized compounds were confirmed by IR 1H and 13NMR spectroscopy. Comparison of conjugation and stereochemistry of the respective derivatives showed similar characteristics compared to ones with some higher degree of conjugation in the ferrocenyl series. Comparison of logP of the ferrocenyl derivatives determined by a validated RP-TLC method showed the ferrocenyl derivatives to have higher logP TLC. The results demonstrate that the differences in three dimensional shape, conjugation and lipophilicity do not have strong influence on the P388 cytotoxicity of the investigated phenyl (1-5) and ferrocenyl (6-10) enones.

Original languageEnglish
Pages (from-to)1500-1505
Number of pages6
JournalCentral European Journal of Chemistry
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Cyclic chalcone analogues
  • Ferrocene
  • IR
  • NMR
  • P388 cytotoxicity
  • RP-TLC logP

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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