Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

Péter Lajos Sóti, Katalin Bocz, Hajnalka Pataki, Zsuzsanna Eke, Attila Farkas, Geert Verreck, E. Kiss, Pál Fekete, Tamás Vigh, István Wagner, Zsombor K. Nagy, G. Marosi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Abstract Three solvent based methods: spray drying (SD), electrospinning (ES) and air-assisted electrospinning (electroblowing; EB) were used to prepare solid dispersions of itraconazole and Eudragit E. Samples with the same API/polymer ratios were prepared in order to make the three technologies comparable. The structure and morphology of solid dispersions were identified by scanning electron microscopy and solid phase analytical methods such as, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman chemical mapping. Moreover, the residual organic solvents of the solid products were determined by static headspace-gas chromatography/mass spectroscopy measurements and the wettability of samples was characterized by contact angle measurement. The pharmaceutical performance of the three dispersion type, evaluated by dissolution tests, proved to be very similar. According to XRPD and DSC analyses, made after the production, all the solid dispersions were free of any API crystal clusters but about 10 wt% drug crystallinity was observed after three months of storage in the case of the SD samples in contrast to the samples produced by ES and EB in which the polymer matrix preserved the API in amorphous state.

Original languageEnglish
Article number15080
Pages (from-to)23-30
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume494
Issue number1
DOIs
Publication statusPublished - Oct 15 2015

Fingerprint

Powder Diffraction
Itraconazole
Differential Scanning Calorimetry
X-Ray Diffraction
Polymers
Wettability
Pharmaceutical Preparations
Gas Chromatography
Electron Scanning Microscopy
Mass Spectrometry
Air
Technology
Eudragit-E

Keywords

  • Electroblowing
  • Electrospinning
  • Itraconazole
  • Raman mapping
  • Rapid dissolution
  • Spray drying

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions. / Sóti, Péter Lajos; Bocz, Katalin; Pataki, Hajnalka; Eke, Zsuzsanna; Farkas, Attila; Verreck, Geert; Kiss, E.; Fekete, Pál; Vigh, Tamás; Wagner, István; Nagy, Zsombor K.; Marosi, G.

In: International Journal of Pharmaceutics, Vol. 494, No. 1, 15080, 15.10.2015, p. 23-30.

Research output: Contribution to journalArticle

Sóti, Péter Lajos ; Bocz, Katalin ; Pataki, Hajnalka ; Eke, Zsuzsanna ; Farkas, Attila ; Verreck, Geert ; Kiss, E. ; Fekete, Pál ; Vigh, Tamás ; Wagner, István ; Nagy, Zsombor K. ; Marosi, G. / Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions. In: International Journal of Pharmaceutics. 2015 ; Vol. 494, No. 1. pp. 23-30.
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AU - Sóti, Péter Lajos

AU - Bocz, Katalin

AU - Pataki, Hajnalka

AU - Eke, Zsuzsanna

AU - Farkas, Attila

AU - Verreck, Geert

AU - Kiss, E.

AU - Fekete, Pál

AU - Vigh, Tamás

AU - Wagner, István

AU - Nagy, Zsombor K.

AU - Marosi, G.

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AB - Abstract Three solvent based methods: spray drying (SD), electrospinning (ES) and air-assisted electrospinning (electroblowing; EB) were used to prepare solid dispersions of itraconazole and Eudragit E. Samples with the same API/polymer ratios were prepared in order to make the three technologies comparable. The structure and morphology of solid dispersions were identified by scanning electron microscopy and solid phase analytical methods such as, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman chemical mapping. Moreover, the residual organic solvents of the solid products were determined by static headspace-gas chromatography/mass spectroscopy measurements and the wettability of samples was characterized by contact angle measurement. The pharmaceutical performance of the three dispersion type, evaluated by dissolution tests, proved to be very similar. According to XRPD and DSC analyses, made after the production, all the solid dispersions were free of any API crystal clusters but about 10 wt% drug crystallinity was observed after three months of storage in the case of the SD samples in contrast to the samples produced by ES and EB in which the polymer matrix preserved the API in amorphous state.

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