Introduction: The degree of glomerular fi ltration rate determines the stages of chronic renal disease and, therefore, knowledge on its estimation is essential. Aims: Two standardized creatinine based estimated glomerular fi ltration rate equations and fi ve equations based on the immunoturbidimetric determination of cystatin C were compared. Methods: The distribution of the analytes and the equations, their relations, as well as the differences among the estimated glomerular fi ltration rates and their chronic kidney disease stages assignments were studied. Results: The equations based on cystatin C classifi ed more patient into stage 1, while the creatinine based ones more into stages 2, 3 and 4. The equations published as Grubb1, Grubb2 and Larsson classifi ed more patients while the equations created by Tan and Sjöström classifi ed fewer into stage 5 compared to the creatinine based equations. The equations of Grubb1 and Grubb2 resulted in the most similar stage assignment. The occurence of stages between 3 and 5 was the lowest using the equation of Sjöström. Conclusions: The different equations for the estimation of glomerular fi ltration rate modify signifi cantly the chronic kidney disease stage assignment which may have an infl uence on the treatment and outcome measures of the patients.
|Translated title of the contribution||Comparison of seven estimated glomerular fi ltration rate equations in kidney patients|
|Number of pages||11|
|Publication status||Published - Mar 1 2013|
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