Comparison of prevalence of toxoplasma and cytomegalovirus infection in cases with fetal ultrasound markers in the second trimester of pregnancy

A. Beke, Krisztina Latkóczy, Gyula Richárd Nagy, Anna Dudnyikova, Ákos Csaba, I. Szabó, C. Papp, J. Rigó

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: To evaluate the prevalence of toxoplasma and cytomegalovirus (CMV) infections in cases of ultrasound anomalies detected in the second trimester of pregnancy. Methods: Serological examinations for toxoplasma and CMV infection were carried out in 655 cases with sonographic findings suggestive of fetal infection, 612 cases with single ultrasound markers and 43 cases with two or more markers. Results: In cases of single ultrasound markers, serological examination diagnosed recent toxoplasma infection in 107/612 cases (17.5%) and recent CMV infection in 75 cases (12.3%). Recent toxoplasma infection accounted for 13.8% (52/377) of the intracranial sonographic findings and 23.9% (45/188) of the abdominal findings, whereas recent CMV infections accounted for 12.2 (46/377) and 11.7% (22/188), respectively. Recent CMV infection with sonographic manifestations had higher rates of intracranial than intra-abdominal sonographic findings (46/75 or 61% vs 22/75 or 29%), whereas recent toxoplasma infection with sonographic manifestations had similar rates of intracranial (52/107 or 49%) and intra-abdominal (45/107 or 42%) findings. In cases of two or more ultrasound markers, serological examination diagnosed recent toxoplasma infection in 12/43 cases (27.9%) and recent CMV infection in 10/43 cases (23.3%). Conclusions: Ultrasound findings suspicious for toxoplasma and CMV infection are not pathognomonic for either pathologic entity.

Original languageEnglish
Pages (from-to)945-948
Number of pages4
JournalPrenatal Diagnosis
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Toxoplasma
Cytomegalovirus Infections
Second Pregnancy Trimester
Infection

Keywords

  • Cytomegalovirus (CMV) infection
  • Pregnancy
  • Toxoplasma infection
  • Ultrasound examination

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

Cite this

Comparison of prevalence of toxoplasma and cytomegalovirus infection in cases with fetal ultrasound markers in the second trimester of pregnancy. / Beke, A.; Latkóczy, Krisztina; Nagy, Gyula Richárd; Dudnyikova, Anna; Csaba, Ákos; Szabó, I.; Papp, C.; Rigó, J.

In: Prenatal Diagnosis, Vol. 31, No. 10, 10.2011, p. 945-948.

Research output: Contribution to journalArticle

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abstract = "Objectives: To evaluate the prevalence of toxoplasma and cytomegalovirus (CMV) infections in cases of ultrasound anomalies detected in the second trimester of pregnancy. Methods: Serological examinations for toxoplasma and CMV infection were carried out in 655 cases with sonographic findings suggestive of fetal infection, 612 cases with single ultrasound markers and 43 cases with two or more markers. Results: In cases of single ultrasound markers, serological examination diagnosed recent toxoplasma infection in 107/612 cases (17.5{\%}) and recent CMV infection in 75 cases (12.3{\%}). Recent toxoplasma infection accounted for 13.8{\%} (52/377) of the intracranial sonographic findings and 23.9{\%} (45/188) of the abdominal findings, whereas recent CMV infections accounted for 12.2 (46/377) and 11.7{\%} (22/188), respectively. Recent CMV infection with sonographic manifestations had higher rates of intracranial than intra-abdominal sonographic findings (46/75 or 61{\%} vs 22/75 or 29{\%}), whereas recent toxoplasma infection with sonographic manifestations had similar rates of intracranial (52/107 or 49{\%}) and intra-abdominal (45/107 or 42{\%}) findings. In cases of two or more ultrasound markers, serological examination diagnosed recent toxoplasma infection in 12/43 cases (27.9{\%}) and recent CMV infection in 10/43 cases (23.3{\%}). Conclusions: Ultrasound findings suspicious for toxoplasma and CMV infection are not pathognomonic for either pathologic entity.",
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AU - Csaba, Ákos

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AU - Papp, C.

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N2 - Objectives: To evaluate the prevalence of toxoplasma and cytomegalovirus (CMV) infections in cases of ultrasound anomalies detected in the second trimester of pregnancy. Methods: Serological examinations for toxoplasma and CMV infection were carried out in 655 cases with sonographic findings suggestive of fetal infection, 612 cases with single ultrasound markers and 43 cases with two or more markers. Results: In cases of single ultrasound markers, serological examination diagnosed recent toxoplasma infection in 107/612 cases (17.5%) and recent CMV infection in 75 cases (12.3%). Recent toxoplasma infection accounted for 13.8% (52/377) of the intracranial sonographic findings and 23.9% (45/188) of the abdominal findings, whereas recent CMV infections accounted for 12.2 (46/377) and 11.7% (22/188), respectively. Recent CMV infection with sonographic manifestations had higher rates of intracranial than intra-abdominal sonographic findings (46/75 or 61% vs 22/75 or 29%), whereas recent toxoplasma infection with sonographic manifestations had similar rates of intracranial (52/107 or 49%) and intra-abdominal (45/107 or 42%) findings. In cases of two or more ultrasound markers, serological examination diagnosed recent toxoplasma infection in 12/43 cases (27.9%) and recent CMV infection in 10/43 cases (23.3%). Conclusions: Ultrasound findings suspicious for toxoplasma and CMV infection are not pathognomonic for either pathologic entity.

AB - Objectives: To evaluate the prevalence of toxoplasma and cytomegalovirus (CMV) infections in cases of ultrasound anomalies detected in the second trimester of pregnancy. Methods: Serological examinations for toxoplasma and CMV infection were carried out in 655 cases with sonographic findings suggestive of fetal infection, 612 cases with single ultrasound markers and 43 cases with two or more markers. Results: In cases of single ultrasound markers, serological examination diagnosed recent toxoplasma infection in 107/612 cases (17.5%) and recent CMV infection in 75 cases (12.3%). Recent toxoplasma infection accounted for 13.8% (52/377) of the intracranial sonographic findings and 23.9% (45/188) of the abdominal findings, whereas recent CMV infections accounted for 12.2 (46/377) and 11.7% (22/188), respectively. Recent CMV infection with sonographic manifestations had higher rates of intracranial than intra-abdominal sonographic findings (46/75 or 61% vs 22/75 or 29%), whereas recent toxoplasma infection with sonographic manifestations had similar rates of intracranial (52/107 or 49%) and intra-abdominal (45/107 or 42%) findings. In cases of two or more ultrasound markers, serological examination diagnosed recent toxoplasma infection in 12/43 cases (27.9%) and recent CMV infection in 10/43 cases (23.3%). Conclusions: Ultrasound findings suspicious for toxoplasma and CMV infection are not pathognomonic for either pathologic entity.

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