Comparison of optimization methods for fed-batch cultures of hybridoma cells

J. Roubos, C. D. De Gooijer, G. Van Straten, A. J B Van Boxtel

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming approach which has been presented in a previous paper [1] as the most suitable method.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalBioprocess Engineering
Volume17
Issue number2
DOIs
Publication statusPublished - 1997

Fingerprint

Batch Cell Culture Techniques
Gradient methods
Hybridomas
Dynamic programming
Trajectories

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Chemical Engineering(all)
  • Bioengineering

Cite this

Comparison of optimization methods for fed-batch cultures of hybridoma cells. / Roubos, J.; De Gooijer, C. D.; Van Straten, G.; Van Boxtel, A. J B.

In: Bioprocess Engineering, Vol. 17, No. 2, 1997, p. 99-102.

Research output: Contribution to journalArticle

Roubos, J. ; De Gooijer, C. D. ; Van Straten, G. ; Van Boxtel, A. J B. / Comparison of optimization methods for fed-batch cultures of hybridoma cells. In: Bioprocess Engineering. 1997 ; Vol. 17, No. 2. pp. 99-102.
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