Comparison of optimization methods for fed-batch cultures of hybridoma cells

J. A. Roubos, C. D. De Gooijer, G. Van Straten, A. J.B. Van Boxtel

Research output: Contribution to journalArticle

27 Citations (Scopus)


Two methods for the calculation of optimal trajectories for the input variables of a fed-batch culture of hybridoma cells are compared. It pointed out that a gradient method based on Pontryagins' minimum principle based yields a significant better performance with respect to computational effort and the calculated minimum than a dynamic programming approach which has been presented in a previous paper [1] as the most suitable method.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalBioprocess Engineering
Issue number2
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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