Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents

Leonard Amaral, Helga Engi, Miguel Viveiros, J. Molnár

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalIn Vivo
Volume21
Issue number2
Publication statusPublished - Mar 2007

Fingerprint

Pumps
Neoplasms
Bacteria
Cells

Keywords

  • Efflux pumps
  • Inhibitory agents
  • MDR bacteria
  • MDR cancer cells
  • Multidrug resistance (MDR)
  • Review

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents. / Amaral, Leonard; Engi, Helga; Viveiros, Miguel; Molnár, J.

In: In Vivo, Vol. 21, No. 2, 03.2007, p. 237-244.

Research output: Contribution to journalArticle

Amaral, Leonard ; Engi, Helga ; Viveiros, Miguel ; Molnár, J. / Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents. In: In Vivo. 2007 ; Vol. 21, No. 2. pp. 237-244.
@article{94031f6e618e400885382785c2cc2d21,
title = "Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents",
abstract = "Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.",
keywords = "Efflux pumps, Inhibitory agents, MDR bacteria, MDR cancer cells, Multidrug resistance (MDR), Review",
author = "Leonard Amaral and Helga Engi and Miguel Viveiros and J. Moln{\'a}r",
year = "2007",
month = "3",
language = "English",
volume = "21",
pages = "237--244",
journal = "In Vivo",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "2",

}

TY - JOUR

T1 - Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents

AU - Amaral, Leonard

AU - Engi, Helga

AU - Viveiros, Miguel

AU - Molnár, J.

PY - 2007/3

Y1 - 2007/3

N2 - Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.

AB - Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.

KW - Efflux pumps

KW - Inhibitory agents

KW - MDR bacteria

KW - MDR cancer cells

KW - Multidrug resistance (MDR)

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=34047222991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047222991&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 237

EP - 244

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 2

ER -