Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents

Leonard Amaral, Helga Engi, Miguel Viveiros, Joseph Molnar

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalIn Vivo
Volume21
Issue number2
Publication statusPublished - Mar 1 2007

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Keywords

  • Efflux pumps
  • Inhibitory agents
  • MDR bacteria
  • MDR cancer cells
  • Multidrug resistance (MDR)
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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