Comparison of membrane fluidity and transferrin receptor expression as proliferation markers in lymphoproliferative disorders and in mitogen induced lymphoblasts

László Pajor, E. Kálmán, T. Kőszegi

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7 Citations (Scopus)

Abstract

The correlation of two proliferation related events, membrane fluidization and transferrin receptor expression was studied in different lymphoid cells. With increasing grade of malignancy the membrane microviscosity decreased. Moreover, resting lymphocytes differed significantly from chronic lymphocytic leukaemia cells in this parameter. [125I]Fe2-transferrin binding increased with increasing proliferation capacity of cells. The membrane microviscosity of mitogen induced blasts was very similar to that of acute lymphoblastic cells, whereas the [125I]Fe2-transferrin binding capacity exceeded roughly 5 times that of the blastic leukaemia cells. This dissociation indicates that these two proliferation markers do not necessarily parallel each other.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalLeukemia Research
Volume12
Issue number6
DOIs
Publication statusPublished - 1988

Fingerprint

Membrane Fluidity
Transferrin Receptors
Lymphoproliferative Disorders
Mitogens
Transferrin
Membranes
Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Leukemia
Cell Proliferation
Neoplasms

Keywords

  • cell proliferation
  • Membrane fluidity
  • transferrin receptor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

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abstract = "The correlation of two proliferation related events, membrane fluidization and transferrin receptor expression was studied in different lymphoid cells. With increasing grade of malignancy the membrane microviscosity decreased. Moreover, resting lymphocytes differed significantly from chronic lymphocytic leukaemia cells in this parameter. [125I]Fe2-transferrin binding increased with increasing proliferation capacity of cells. The membrane microviscosity of mitogen induced blasts was very similar to that of acute lymphoblastic cells, whereas the [125I]Fe2-transferrin binding capacity exceeded roughly 5 times that of the blastic leukaemia cells. This dissociation indicates that these two proliferation markers do not necessarily parallel each other.",
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T1 - Comparison of membrane fluidity and transferrin receptor expression as proliferation markers in lymphoproliferative disorders and in mitogen induced lymphoblasts

AU - Pajor, László

AU - Kálmán, E.

AU - Kőszegi, T.

PY - 1988

Y1 - 1988

N2 - The correlation of two proliferation related events, membrane fluidization and transferrin receptor expression was studied in different lymphoid cells. With increasing grade of malignancy the membrane microviscosity decreased. Moreover, resting lymphocytes differed significantly from chronic lymphocytic leukaemia cells in this parameter. [125I]Fe2-transferrin binding increased with increasing proliferation capacity of cells. The membrane microviscosity of mitogen induced blasts was very similar to that of acute lymphoblastic cells, whereas the [125I]Fe2-transferrin binding capacity exceeded roughly 5 times that of the blastic leukaemia cells. This dissociation indicates that these two proliferation markers do not necessarily parallel each other.

AB - The correlation of two proliferation related events, membrane fluidization and transferrin receptor expression was studied in different lymphoid cells. With increasing grade of malignancy the membrane microviscosity decreased. Moreover, resting lymphocytes differed significantly from chronic lymphocytic leukaemia cells in this parameter. [125I]Fe2-transferrin binding increased with increasing proliferation capacity of cells. The membrane microviscosity of mitogen induced blasts was very similar to that of acute lymphoblastic cells, whereas the [125I]Fe2-transferrin binding capacity exceeded roughly 5 times that of the blastic leukaemia cells. This dissociation indicates that these two proliferation markers do not necessarily parallel each other.

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KW - transferrin receptor

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