Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma

15-Year results

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Invasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease. Aim: The current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC. Material and methods: Study includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n=163) or BCS (n=72). 50. Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group. Results: Patients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62% vs. 70%; p, 0.2017) and breast cancer-specific (62% vs. 70%; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10% with and 53% without RT at 15 years (relative risk [RR], 0.10; p

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalReports of Practical Oncology and Radiotherapy
Volume16
Issue number6
DOIs
Publication statusPublished - Nov 2011

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Lobular Carcinoma
Segmental Mastectomy
Mastectomy
Neoplasms
Adjuvant Radiotherapy
Disease Management
Dissection
Breast
Radiotherapy
Breast Neoplasms
Neoplasm Metastasis
Recurrence
Survival

Keywords

  • Breast-conserving therapy
  • Invasive lobular breast cancer
  • Mastectomy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma: 15-Year results",
abstract = "Background: Invasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease. Aim: The current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC. Material and methods: Study includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n=163) or BCS (n=72). 50. Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group. Results: Patients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62{\%} vs. 70{\%}; p, 0.2017) and breast cancer-specific (62{\%} vs. 70{\%}; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10{\%} with and 53{\%} without RT at 15 years (relative risk [RR], 0.10; p",
keywords = "Breast-conserving therapy, Invasive lobular breast cancer, Mastectomy",
author = "J. Fodor and T. Major and J. T{\'o}th and Z. Sulyok and C. Polg{\'a}r",
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T1 - Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma

T2 - 15-Year results

AU - Fodor, J.

AU - Major, T.

AU - Tóth, J.

AU - Sulyok, Z.

AU - Polgár, C.

PY - 2011/11

Y1 - 2011/11

N2 - Background: Invasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease. Aim: The current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC. Material and methods: Study includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n=163) or BCS (n=72). 50. Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group. Results: Patients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62% vs. 70%; p, 0.2017) and breast cancer-specific (62% vs. 70%; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10% with and 53% without RT at 15 years (relative risk [RR], 0.10; p

AB - Background: Invasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease. Aim: The current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC. Material and methods: Study includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n=163) or BCS (n=72). 50. Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group. Results: Patients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62% vs. 70%; p, 0.2017) and breast cancer-specific (62% vs. 70%; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10% with and 53% without RT at 15 years (relative risk [RR], 0.10; p

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KW - Invasive lobular breast cancer

KW - Mastectomy

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