Comparison of mass spectrometric methods for studying thermally labile compounds: Rifapentine

K. Vékey, Duncan M F Edwards, Luigi F. Zerilli, Marianna Màk, Jòzsef Tamàs, Vittorio Raverdino, Antonio Selva

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Results of 16 different mass spectrometric ionization and sample‐introduction methods are compared for the case of a thermally very labile antibiotic, rifapentine. These suggest that extensive thermal decomposition occurs during evaporation when the sample can come into contact with hot metal parts, usually the source housing. The intensity of the molecular ion and the extent of fragmentation depend on various parameters, such as the ionization process, positive or negative‐ion detection and the type of sample introduction. The most informative methods for rifapentine seem to be ‘in‐beam’ electron impact, negative ionization with particle beam and direct liquid introduction interfaces and positive‐ and negative‐ion fast atom bombardment.

Original languageEnglish
Pages (from-to)465-474
Number of pages10
JournalOrganic Mass Spectrometry
Volume25
Issue number9
DOIs
Publication statusPublished - 1990

Fingerprint

rifapentine
Ionization
ionization
Particle beams
antibiotics
Hot Temperature
Metals
particle beams
Antibiotics
Electrons
Ions
Anti-Bacterial Agents
molecular ions
electron impact
thermal decomposition
bombardment
fragmentation
Evaporation
Pyrolysis
evaporation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Instrumentation

Cite this

Vékey, K., Edwards, D. M. F., Zerilli, L. F., Màk, M., Tamàs, J., Raverdino, V., & Selva, A. (1990). Comparison of mass spectrometric methods for studying thermally labile compounds: Rifapentine. Organic Mass Spectrometry, 25(9), 465-474. https://doi.org/10.1002/oms.1210250907

Comparison of mass spectrometric methods for studying thermally labile compounds : Rifapentine. / Vékey, K.; Edwards, Duncan M F; Zerilli, Luigi F.; Màk, Marianna; Tamàs, Jòzsef; Raverdino, Vittorio; Selva, Antonio.

In: Organic Mass Spectrometry, Vol. 25, No. 9, 1990, p. 465-474.

Research output: Contribution to journalArticle

Vékey, K, Edwards, DMF, Zerilli, LF, Màk, M, Tamàs, J, Raverdino, V & Selva, A 1990, 'Comparison of mass spectrometric methods for studying thermally labile compounds: Rifapentine', Organic Mass Spectrometry, vol. 25, no. 9, pp. 465-474. https://doi.org/10.1002/oms.1210250907
Vékey, K. ; Edwards, Duncan M F ; Zerilli, Luigi F. ; Màk, Marianna ; Tamàs, Jòzsef ; Raverdino, Vittorio ; Selva, Antonio. / Comparison of mass spectrometric methods for studying thermally labile compounds : Rifapentine. In: Organic Mass Spectrometry. 1990 ; Vol. 25, No. 9. pp. 465-474.
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