Comparison of lithium and sodium transports in primary cultures of dissociated brain cells

I. Szentistvanyi, Z. Janka, A. Rimanóczy, L. Latzkovits, A. Juhász

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Abstract

Lithium and sodium transports were studied in primary cultures of dissociated brain cells from chick embryos. The uptake of lithium into the cells achieved steady-state depending on the external sodium concentration. Ouabain did not influence the rates of either influx or efflux of lithium while uptake of sodium was significantly increased by the presence of ouabain. Our data provide evidence that lithium ion enters the cells through the sodium transport pathway which is ouabain-insensitive. Intracellular levels of sodium and lithium, when both taken up together, corresponded to the external sodium per lithium concentration. Similarities and differences in lithium and sodium transports suggest the possibility of a lithium-sodium exchange in nerve cell culture.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalCellular and Molecular Biology
Volume25
Issue number5
Publication statusPublished - 1979

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Lithium
Brain
Sodium
Ouabain
Chick Embryo
Cell culture
Neurons
Cell Culture Techniques
Ions

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Comparison of lithium and sodium transports in primary cultures of dissociated brain cells. / Szentistvanyi, I.; Janka, Z.; Rimanóczy, A.; Latzkovits, L.; Juhász, A.

In: Cellular and Molecular Biology, Vol. 25, No. 5, 1979, p. 315-321.

Research output: Contribution to journalArticle

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AU - Juhász, A.

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