Comparison of lactase persistence polymorphism in ancient and present-day Hungarian populations

Dóra Nagy, Gyöngyvér Tömöry, Bernadett Csányi, Erika Bogácsi-Szabó, Ágnes Czibula, Katalin Priskin, Olga Bede, László Bartosiewicz, C. Stephen Downes, István Raskó

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26 Citations (Scopus)

Abstract

The prevalence of adult-type hypolactasia varies ethnically and geographically among populations. A C/T-13910 single nucleotide polymorphism (SNP) upstream of the lactase gene is known to be associated with lactase non-persistence in Europeans. The aim of this study was to determine the prevalence of lactase persistent and non-persistent genotypes in current Hungarian-speaking populations and in ancient bone samples of classical conquerors and commoners from the 10th-11th centuries from the Carpathian basin; 181 present-day Hungarian, 65 present-day Sekler, and 23 ancient samples were successfully genotyped for the C/T-13910 SNP by the dCAPS PCR-RFLP method. Additional mitochondrial DNA testing was also carried out. In ancient Hungarians, the T-13910 allele was present only in 11% of the population, and exclusively in commoners of European mitochondrial haplogroups who may have been of pre-Hungarian indigenous ancestry. This is despite animal domestication and dairy products having been introduced into the Carpathian basin early in the Neolithic Age. This anomaly may be explained by the Hungarian use of fermented milk products, their greater consumption of ruminant meat than milk, cultural differences, or by their having other lactase-regulating genetic polymorphisms than C/T-13910. The low prevalence of lactase persistence provides additional information on the Asian origin of Hungarians. Present-day Hungarians have been assimilated with the surrounding European populations, since they do not differ significantly from the neighboring populations in their possession of mtDNA and C/T-13910 variants.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalAmerican Journal of Physical Anthropology
Volume145
Issue number2
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • 10th-11th century bones
  • ancient DNA
  • lactose intolerance
  • mitochondrial DNA

ASJC Scopus subject areas

  • Anatomy
  • Anthropology

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    Nagy, D., Tömöry, G., Csányi, B., Bogácsi-Szabó, E., Czibula, Á., Priskin, K., Bede, O., Bartosiewicz, L., Downes, C. S., & Raskó, I. (2011). Comparison of lactase persistence polymorphism in ancient and present-day Hungarian populations. American Journal of Physical Anthropology, 145(2), 262-269. https://doi.org/10.1002/ajpa.21490