Comparison of inhibitory effects of atropine, cimetidine, and atropine plus cimetidine on the indomethacin-provoked gastric mucosal erosions in rats

F. Tarnok, G. Mozsik, T. Javor

Research output: Contribution to journalArticle

Abstract

20 mg/kg-1 indomethacin suspended in 1% carboxymethyl-cellulose solution was given subcutaneously into rats to provoke gastric mucosal erosions during 5 h. Dose-dependent inhibitions of indomethacin erosions were observed following different doses of atropine (0.025; 0.2; 1.0 mg/kg-1) and cimetidine (2.5; 10; 50 mg/kg-1) administered intraperitoneally (25%; 38%; 81% and 0%; 42%; 89% respectively). More pronounced inhibitory effects have been obtained with the combinations of both drugs (51%; 68%; 92%). In particular there was a remarkable potentiated synergism in the lowest doses of atropine and cimetidine (51%, against 0% and 25%). These results provide further evidence of synergism of histamine H2-receptor blockers and anticholinergics, which combinations would be useful, for example, in peptic ulcer therapy.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalInternational Journal of Tissue Reactions
Volume8
Issue number1
Publication statusPublished - Jan 1 1986

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Physiology
  • Immunology
  • Cell Biology

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