Comparison of inflammatory response following coronary revascularization with or without cardiopulmonary bypass

B. Gasz, László Benkö, Gb́or Jancsó, J. Lantos, Zalán Szátó, Nasri Alotti, E. Rőth

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: It is well known that conventional coronary revascularization is associated with a pronounced systemic inflammatory response due to the application of cardiopulmonary bypass (CPB). Objective: To compare the effects of coronary artery bypass grafting (CABG) with (on-pump) or without (off-pump) extra-corporeal circulation observing certain inflammatory response parameters. Methods: Twenty patients undergoing CABG with (CPB group: 10 patients) or without (off-pump coronary artery bypass grafting [OPCAB] group: 10 patients) CPB were enrolled in this prospective, randomized study. Blood samples were collected three times during the operation and on postoperative days 1, 2, 3 and 7. The plasma level of proinflammatory cytokine tumor necrosis factor (TNF)-alpha was measured by enzyme-linked immunosorbent assay method following stimulation, and the expression of adhesion molecules (CD11, CD18) of leukocytes were determined by flow cytometry. Furthermore, white blood cell (WBC) and neutrophil count were carried out. Results: The WBC and neutrophil counts rose markedly in both groups following the operation and remained at this increased level during the observation period. There was a significant difference in WBC and neutrophil counts between the two groups of patients on postoperative day 7. A significant difference in the level of TNF-alpha was found between the two groups on postoperative day 2 (P

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalExperimental and Clinical Cardiology
Volume9
Issue number1
Publication statusPublished - 2004

Fingerprint

Cardiopulmonary Bypass
Leukocyte Count
Coronary Artery Bypass
Neutrophils
Tumor Necrosis Factor-alpha
Off-Pump Coronary Artery Bypass
Flow Cytometry
Leukocytes
Enzyme-Linked Immunosorbent Assay
Observation
Prospective Studies
Cytokines

Keywords

  • Adhesion molecule
  • Cardiopulmonary bypass
  • Coronary bypass
  • Cytokines

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of inflammatory response following coronary revascularization with or without cardiopulmonary bypass. / Gasz, B.; Benkö, László; Jancsó, Gb́or; Lantos, J.; Szátó, Zalán; Alotti, Nasri; Rőth, E.

In: Experimental and Clinical Cardiology, Vol. 9, No. 1, 2004, p. 26-30.

Research output: Contribution to journalArticle

@article{62fefea385824cb49738d350fff6cc19,
title = "Comparison of inflammatory response following coronary revascularization with or without cardiopulmonary bypass",
abstract = "Background: It is well known that conventional coronary revascularization is associated with a pronounced systemic inflammatory response due to the application of cardiopulmonary bypass (CPB). Objective: To compare the effects of coronary artery bypass grafting (CABG) with (on-pump) or without (off-pump) extra-corporeal circulation observing certain inflammatory response parameters. Methods: Twenty patients undergoing CABG with (CPB group: 10 patients) or without (off-pump coronary artery bypass grafting [OPCAB] group: 10 patients) CPB were enrolled in this prospective, randomized study. Blood samples were collected three times during the operation and on postoperative days 1, 2, 3 and 7. The plasma level of proinflammatory cytokine tumor necrosis factor (TNF)-alpha was measured by enzyme-linked immunosorbent assay method following stimulation, and the expression of adhesion molecules (CD11, CD18) of leukocytes were determined by flow cytometry. Furthermore, white blood cell (WBC) and neutrophil count were carried out. Results: The WBC and neutrophil counts rose markedly in both groups following the operation and remained at this increased level during the observation period. There was a significant difference in WBC and neutrophil counts between the two groups of patients on postoperative day 7. A significant difference in the level of TNF-alpha was found between the two groups on postoperative day 2 (P",
keywords = "Adhesion molecule, Cardiopulmonary bypass, Coronary bypass, Cytokines",
author = "B. Gasz and L{\'a}szl{\'o} Benk{\"o} and Gb́or Jancs{\'o} and J. Lantos and Zal{\'a}n Sz{\'a}t{\'o} and Nasri Alotti and E. Rőth",
year = "2004",
language = "English",
volume = "9",
pages = "26--30",
journal = "Experimental and Clinical Cardiology",
issn = "1205-6626",
publisher = "Pulsus Group Inc.",
number = "1",

}

TY - JOUR

T1 - Comparison of inflammatory response following coronary revascularization with or without cardiopulmonary bypass

AU - Gasz, B.

AU - Benkö, László

AU - Jancsó, Gb́or

AU - Lantos, J.

AU - Szátó, Zalán

AU - Alotti, Nasri

AU - Rőth, E.

PY - 2004

Y1 - 2004

N2 - Background: It is well known that conventional coronary revascularization is associated with a pronounced systemic inflammatory response due to the application of cardiopulmonary bypass (CPB). Objective: To compare the effects of coronary artery bypass grafting (CABG) with (on-pump) or without (off-pump) extra-corporeal circulation observing certain inflammatory response parameters. Methods: Twenty patients undergoing CABG with (CPB group: 10 patients) or without (off-pump coronary artery bypass grafting [OPCAB] group: 10 patients) CPB were enrolled in this prospective, randomized study. Blood samples were collected three times during the operation and on postoperative days 1, 2, 3 and 7. The plasma level of proinflammatory cytokine tumor necrosis factor (TNF)-alpha was measured by enzyme-linked immunosorbent assay method following stimulation, and the expression of adhesion molecules (CD11, CD18) of leukocytes were determined by flow cytometry. Furthermore, white blood cell (WBC) and neutrophil count were carried out. Results: The WBC and neutrophil counts rose markedly in both groups following the operation and remained at this increased level during the observation period. There was a significant difference in WBC and neutrophil counts between the two groups of patients on postoperative day 7. A significant difference in the level of TNF-alpha was found between the two groups on postoperative day 2 (P

AB - Background: It is well known that conventional coronary revascularization is associated with a pronounced systemic inflammatory response due to the application of cardiopulmonary bypass (CPB). Objective: To compare the effects of coronary artery bypass grafting (CABG) with (on-pump) or without (off-pump) extra-corporeal circulation observing certain inflammatory response parameters. Methods: Twenty patients undergoing CABG with (CPB group: 10 patients) or without (off-pump coronary artery bypass grafting [OPCAB] group: 10 patients) CPB were enrolled in this prospective, randomized study. Blood samples were collected three times during the operation and on postoperative days 1, 2, 3 and 7. The plasma level of proinflammatory cytokine tumor necrosis factor (TNF)-alpha was measured by enzyme-linked immunosorbent assay method following stimulation, and the expression of adhesion molecules (CD11, CD18) of leukocytes were determined by flow cytometry. Furthermore, white blood cell (WBC) and neutrophil count were carried out. Results: The WBC and neutrophil counts rose markedly in both groups following the operation and remained at this increased level during the observation period. There was a significant difference in WBC and neutrophil counts between the two groups of patients on postoperative day 7. A significant difference in the level of TNF-alpha was found between the two groups on postoperative day 2 (P

KW - Adhesion molecule

KW - Cardiopulmonary bypass

KW - Coronary bypass

KW - Cytokines

UR - http://www.scopus.com/inward/record.url?scp=2942661467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942661467&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 26

EP - 30

JO - Experimental and Clinical Cardiology

JF - Experimental and Clinical Cardiology

SN - 1205-6626

IS - 1

ER -