Comparison of individual and combined effects of four endocrine disruptors on estrogen receptor beta transcription in cerebellar cell culture: The modulatory role of estradiol and triiodo-thyronine

Gergely Jocsak, David Sandor Kiss, I. Tóth, Greta Goszleth, T. Bartha, L. Frenyó, Tamas L. Horvath, A. Zsarnovszky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Humans and animals are continuously exposed to a number of environmental substances that act as endocrine disruptors (EDs). While a growing body of evidence is available to prove their adverse health effects, very little is known about the consequences of simultaneous exposure to a combination of such chemicals; Methods: Here, we used an in vitro model to demonstrate how exposure to bisphenol A, zearalenone, arsenic, and 4-methylbenzylidene camphor, alone or in combination, affect estrogen recepto β (ERβ) mRNA expression in primary cerebellar cell cultures. Additionally, we also show the modulatory role of intrinsic biological factors, such as estradiol (E2), triiodo-thyronine (T3), and glial cells, as potential effect modulators; Results: Results show a wide diversity in ED effects on ERβ mRNA expression, and that the magnitude of these ED effects highly depends on the presence or absence of E2, T3, and glial cells; Conclusion: The observed potency of the EDs to influence ERβ mRNA expression, and the modulatory role of E2, T3, and the glia suggests that environmental ED effects may be masked as long as the hormonal milieu is physiological, but may tend to turn additive or superadditive in case of hormone deficiency.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 22 2016

Keywords

  • Arsenic
  • Bisphenol A
  • Camphor
  • Combined treatment
  • Estrogen receptor beta
  • Transcription
  • Zearalenone

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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