In vitro vizsgalati modellek eredmenyeinek osszehasonlitasa a kupok hatoanyagleadasa szempontjabol

Translated title of the contribution: Comparison of in vitro model examinations with respect to drug release from suppositories

G. Ifj Regdon, I. Vago, E. Mandi, G. Regdon, I. Eros

Research output: Contribution to journalArticle

Abstract

9 lipophilic suppository bases with different physical-chemical parameters were examined. Buspiron-hydrochloride, an anxiolytic drug with good water-solubility was used - partly as a model - as a pharmacon, in a concentration of 10.0 mg/2.00g. The rate and extent of in vitro drug release was monitored with static and dynamic methods. Kidney-dialysing membranes with various surfaces were used. The quantitative measurements were carried out spectrophotometrically and the amount of the diffused drug was determined at λ= 298 nm. The mean values were calculated from 5 parallel measurements each time. The percentage values of in vitro relative availability revealed that the results of the two static diffusion studies did not differ significantly (p <0.05) and were almost independent of the size of the membrane surface. The results of the dynamic diffusion method were well-reproducible but were vehicle-dependent. The process of release was characterized by the mathematical transformation of the release curves, while the correlation coefficients described the closeness of the relation. Two German vehicles, namely Witepsol H 15 with a medium hydroxyl value and Massa Estarinum 299, and a French vehicle, Suppocire AS2X were found to be excellent for the formulation of suppositories containing Buspiron-hydrochloride.

Translated title of the contributionComparison of in vitro model examinations with respect to drug release from suppositories
Original languageHungarian
Pages (from-to)45-51
Number of pages7
JournalActa pharmaceutica Hungarica
Volume70
Issue number2
Publication statusPublished - Jan 1 2000

ASJC Scopus subject areas

  • Pharmaceutical Science

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