Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time

Dineke Frentz, Charles A B Boucher, Matthias Assel, Andrea de Luca, Massimiliano Fabbiani, Francesca Incardona, Pieter Libin, Nino Manca, V. Müller, Breanndán Ó Nualláin, Roger Paredes, Mattia Prosperi, Eugenia Quiros-Roldan, Lidia Ruiz, Peter M A Sloot, Carlo Torti, Anne Mieke Vandamme, Kristel van Laethem, Maurizio Zazzi, David A M C van de Vijver

Research output: Contribution to journalArticle

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Abstract

Background: Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. Methodology/Principal Findings: Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was available at the time of changing treatment with at least one follow-up viral load measurement. Genotypic susceptibility scores for the active regimens were calculated using scores defined by each interpretation system. Using logistic regression, we determined the association between the genotypic susceptibility score and proportion of TCEs having an undetectable viral load (

Original languageEnglish
Article numbere11505
JournalPLoS One
Volume5
Issue number7
DOIs
Publication statusPublished - 2010

Fingerprint

viral load
Human immunodeficiency virus 1
Decision support systems
Viral Load
Logistics
HIV-1
drug resistance
decision support systems
Drug Resistance
Pharmaceutical Preparations
genotyping
Logistic Models
Genotype
testing
genotype
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Frentz, D., Boucher, C. A. B., Assel, M., de Luca, A., Fabbiani, M., Incardona, F., ... van de Vijver, D. A. M. C. (2010). Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time. PLoS One, 5(7), [e11505]. https://doi.org/10.1371/journal.pone.0011505

Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time. / Frentz, Dineke; Boucher, Charles A B; Assel, Matthias; de Luca, Andrea; Fabbiani, Massimiliano; Incardona, Francesca; Libin, Pieter; Manca, Nino; Müller, V.; Nualláin, Breanndán Ó; Paredes, Roger; Prosperi, Mattia; Quiros-Roldan, Eugenia; Ruiz, Lidia; Sloot, Peter M A; Torti, Carlo; Vandamme, Anne Mieke; van Laethem, Kristel; Zazzi, Maurizio; van de Vijver, David A M C.

In: PLoS One, Vol. 5, No. 7, e11505, 2010.

Research output: Contribution to journalArticle

Frentz, D, Boucher, CAB, Assel, M, de Luca, A, Fabbiani, M, Incardona, F, Libin, P, Manca, N, Müller, V, Nualláin, BÓ, Paredes, R, Prosperi, M, Quiros-Roldan, E, Ruiz, L, Sloot, PMA, Torti, C, Vandamme, AM, van Laethem, K, Zazzi, M & van de Vijver, DAMC 2010, 'Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time', PLoS One, vol. 5, no. 7, e11505. https://doi.org/10.1371/journal.pone.0011505
Frentz, Dineke ; Boucher, Charles A B ; Assel, Matthias ; de Luca, Andrea ; Fabbiani, Massimiliano ; Incardona, Francesca ; Libin, Pieter ; Manca, Nino ; Müller, V. ; Nualláin, Breanndán Ó ; Paredes, Roger ; Prosperi, Mattia ; Quiros-Roldan, Eugenia ; Ruiz, Lidia ; Sloot, Peter M A ; Torti, Carlo ; Vandamme, Anne Mieke ; van Laethem, Kristel ; Zazzi, Maurizio ; van de Vijver, David A M C. / Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time. In: PLoS One. 2010 ; Vol. 5, No. 7.
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