Comparison of histochemical and biochemical methods in the evaluation of estrogen and progesterone receptor level in human breast cancer. A study of 118 cases.

J. Mohácsy, A. Kádár, K. Vallent, L. Duffek, K. Vass

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Abstract

Unselected surgical specimens from 118 cancerous breasts of female patients were studied by histochemistry for the presence of cellular estrogen (ER) and progesterone (PR) receptors. The receptor tracers used were 17 beta-estradiol-6-carboxymethyl-oxim-bovine serum albumin - fluorescein isothiocyanate and 11 alpha-hydroxyprogesterone-hemisuccinate-bovine serum albumin-tetramethylrodamine isothiocyanate conjugate (Fluoro-CepTM). Out of 118 carcinomas 77 (67%) proved to be positive in the ER and 79 (66%) in the PR test. The histochemical results were compared with the results of the biochemical assay in 70 cases. A positive correlation was found in 57 cases.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalActa Chirurgica Hungarica
Volume29
Issue number1
Publication statusPublished - 1988

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Progesterone Receptors
Bovine Serum Albumin
Estrogen Receptors
Progesterone
Estradiol
Estrogens
Breast
Breast Neoplasms
Carcinoma
11-hydroxyprogesterone
isothiocyanic acid
fluorescein isothiocyanate bovine serum albumin

ASJC Scopus subject areas

  • Surgery

Cite this

Comparison of histochemical and biochemical methods in the evaluation of estrogen and progesterone receptor level in human breast cancer. A study of 118 cases. / Mohácsy, J.; Kádár, A.; Vallent, K.; Duffek, L.; Vass, K.

In: Acta Chirurgica Hungarica, Vol. 29, No. 1, 1988, p. 95-105.

Research output: Contribution to journalArticle

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