Comparison of enantiomer separation by inclusion chromatography and by resolution via diastereoisomeric salt formation

B. Zsadon, M. Ács, E. Fogassy, F. Faigl, C. Novák, G. Pokol, A. Ujházy

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7 Citations (Scopus)

Abstract

Enantiomers of 6,7-dihydroxy-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride were separated via diastereoisomeric salt formation using optically active tartaric acid, by inclusion-complex formation using water-soluble cyclodextrin polymer, and by inclusion chromatography on β-cyclodextrin bead polymer. On a microscale, the chromatographic resolution has significant advantages over the traditional methods.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalReactive polymers. Ion exchangers, sorbents
Volume6
Issue number2-3
DOIs
Publication statusPublished - 1987

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Enantiomers
Cyclodextrins
Chromatography
chromatography
polymer
Salts
salt
formation water
Polymers
Acids
Water
acid
comparison
cyclodextrin polymer
tartaric acid
1,2,3,4-tetrahydroisoquinoline
complex formation
method

Cite this

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T1 - Comparison of enantiomer separation by inclusion chromatography and by resolution via diastereoisomeric salt formation

AU - Zsadon, B.

AU - Ács, M.

AU - Fogassy, E.

AU - Faigl, F.

AU - Novák, C.

AU - Pokol, G.

AU - Ujházy, A.

PY - 1987

Y1 - 1987

N2 - Enantiomers of 6,7-dihydroxy-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride were separated via diastereoisomeric salt formation using optically active tartaric acid, by inclusion-complex formation using water-soluble cyclodextrin polymer, and by inclusion chromatography on β-cyclodextrin bead polymer. On a microscale, the chromatographic resolution has significant advantages over the traditional methods.

AB - Enantiomers of 6,7-dihydroxy-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride were separated via diastereoisomeric salt formation using optically active tartaric acid, by inclusion-complex formation using water-soluble cyclodextrin polymer, and by inclusion chromatography on β-cyclodextrin bead polymer. On a microscale, the chromatographic resolution has significant advantages over the traditional methods.

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JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

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