Comparison of efficacy and local tolerability of estradiol metered-dose transdermal spray to estradiol patch in a network meta-analysis

G. Kovács, T. Zelei, Z. Vokó

Research output: Contribution to journalArticle

Abstract

Objectives: Transdermal hormone replacement therapy is preferred for menopausal vasomotor symptoms. Our purpose was to compare the efficacy and local tolerability of a patch and a metered-dose transdermal spray that have never been directly compared. Method: The relative change in the number of hot flushes between baseline and week 12 was selected as an efficacy indicator and the frequency of local skin reactions as a tolerability indicator. A network meta-analysis was performed to compare efficacy. Application site tolerability was compared descriptively. Results: Overall 46 studies were identified. In the efficacy analysis, eight active treatment arms and a placebo arm were determined based on the estradiol daily dose (from 14 μg to 50 μg). All but one had a significantly higher effect on relative change in the number of hot flushes than did the placebo. We found no evidence for different efficacy of the patch and the metered-dose transdermal spray. The latter performed better in terms of local skin reactions. Conclusion: The patch and the metered-dose transdermal spray seem to have the same efficacy on vasomotor symptoms in estradiol hormone replacement. The local tolerability of the metered-dose transdermal spray is favorable.

Original languageEnglish
Pages (from-to)488-495
Number of pages8
JournalClimacteric
Volume19
Issue number5
DOIs
Publication statusPublished - Sep 2 2016

Keywords

  • Estradiol
  • efficacy
  • local tolerability
  • metered-dose transdermal spray
  • network meta-analysis
  • patch
  • safety

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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