Comparison of diagnostic accuracy of the RTVue Fourier-domain OCT and the GDX-VCC/ECC polarimeter to detect glaucoma

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Abstract

Purpose. To compare sensitivity and specificity of retinal nerve fiber layer thickness (RNFLT) measurements made using RTVue-100 Fourier-domain optical coherence tomography (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) or enhanced compensation (GDx-ECC). methods. One eye of each of 177 consecutive patients was imaged. Healthy (n=50) and ocular hypertensive (n=28) eyes were defined as structurally undamaged, preperimetric (n=33) and perimetric (n=66) glaucoma eyes as diseased. results. For average RNFLT, sensitivity was higher (χ 2 test, p=0.002) with RTVue-OCT (65.7%) than with GDx-VCC (49.5%). For superior and inferior RNFLT, sensitivity was similar with all methods. For the different nerve fiber bundle parameters, sensitivity of RTVue-OCT (64.6% to 84.8%) was consistently up to 35% higher (p<0.001) than that of GDx-VCC/ECC (28.3% to 72.7%). Specificity ranged from 84.6% to 98.7% with RTVue-OCT, 92.3% to 100% with GDx-VCC, and 94.9% to 100% with GDx-ECC, with no significant difference between the methods except for one nerve fiber bundle parameter, for which RTVue-OCT was less specific than eiher GDx method (p<0.004). Diagnostic accuracy of the GDx-VCC/ECC nerve fiber indicator (NFI) and RTVue-OCT average RNFLT were similar. Of the detected glaucoma cases, 87.7% were identified both by GDx-VCC/ECC NFI and average RNFLT of RTVue-OCT. ConClusions. In this clinical setting, all methods were similarly highly specific, but for localized RNFLT damage RTVue-OCT was statistically and clinically significantly more sensitive than GDx-VCC and GDx-ECC. Most detected glaucoma cases were identified with all 3 methods.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalEuropean Journal of Ophthalmology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

Keywords

  • Diagnostic accuracy
  • Fourier-domain optical coherence tomography
  • Glaucoma
  • Scanning laser polarimetry
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Ophthalmology

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