Comparison of diagnostic accuracy of the RTVue Fourier-domain OCT and the GDX-VCC/ECC polarimeter to detect glaucoma

Anita Garas, P. Vargha, G. Holló

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose. To compare sensitivity and specificity of retinal nerve fiber layer thickness (RNFLT) measurements made using RTVue-100 Fourier-domain optical coherence tomography (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) or enhanced compensation (GDx-ECC). methods. One eye of each of 177 consecutive patients was imaged. Healthy (n=50) and ocular hypertensive (n=28) eyes were defined as structurally undamaged, preperimetric (n=33) and perimetric (n=66) glaucoma eyes as diseased. results. For average RNFLT, sensitivity was higher (χ 2 test, p=0.002) with RTVue-OCT (65.7%) than with GDx-VCC (49.5%). For superior and inferior RNFLT, sensitivity was similar with all methods. For the different nerve fiber bundle parameters, sensitivity of RTVue-OCT (64.6% to 84.8%) was consistently up to 35% higher (p

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalEuropean Journal of Ophthalmology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Nerve Fibers
Glaucoma
Optical Coherence Tomography
Scanning Laser Polarimetry
Eye Diseases
Sensitivity and Specificity

Keywords

  • Diagnostic accuracy
  • Fourier-domain optical coherence tomography
  • Glaucoma
  • Scanning laser polarimetry
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Comparison of diagnostic accuracy of the RTVue Fourier-domain OCT and the GDX-VCC/ECC polarimeter to detect glaucoma",
abstract = "Purpose. To compare sensitivity and specificity of retinal nerve fiber layer thickness (RNFLT) measurements made using RTVue-100 Fourier-domain optical coherence tomography (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) or enhanced compensation (GDx-ECC). methods. One eye of each of 177 consecutive patients was imaged. Healthy (n=50) and ocular hypertensive (n=28) eyes were defined as structurally undamaged, preperimetric (n=33) and perimetric (n=66) glaucoma eyes as diseased. results. For average RNFLT, sensitivity was higher (χ 2 test, p=0.002) with RTVue-OCT (65.7{\%}) than with GDx-VCC (49.5{\%}). For superior and inferior RNFLT, sensitivity was similar with all methods. For the different nerve fiber bundle parameters, sensitivity of RTVue-OCT (64.6{\%} to 84.8{\%}) was consistently up to 35{\%} higher (p",
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AU - Vargha, P.

AU - Holló, G.

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N2 - Purpose. To compare sensitivity and specificity of retinal nerve fiber layer thickness (RNFLT) measurements made using RTVue-100 Fourier-domain optical coherence tomography (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) or enhanced compensation (GDx-ECC). methods. One eye of each of 177 consecutive patients was imaged. Healthy (n=50) and ocular hypertensive (n=28) eyes were defined as structurally undamaged, preperimetric (n=33) and perimetric (n=66) glaucoma eyes as diseased. results. For average RNFLT, sensitivity was higher (χ 2 test, p=0.002) with RTVue-OCT (65.7%) than with GDx-VCC (49.5%). For superior and inferior RNFLT, sensitivity was similar with all methods. For the different nerve fiber bundle parameters, sensitivity of RTVue-OCT (64.6% to 84.8%) was consistently up to 35% higher (p

AB - Purpose. To compare sensitivity and specificity of retinal nerve fiber layer thickness (RNFLT) measurements made using RTVue-100 Fourier-domain optical coherence tomography (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) or enhanced compensation (GDx-ECC). methods. One eye of each of 177 consecutive patients was imaged. Healthy (n=50) and ocular hypertensive (n=28) eyes were defined as structurally undamaged, preperimetric (n=33) and perimetric (n=66) glaucoma eyes as diseased. results. For average RNFLT, sensitivity was higher (χ 2 test, p=0.002) with RTVue-OCT (65.7%) than with GDx-VCC (49.5%). For superior and inferior RNFLT, sensitivity was similar with all methods. For the different nerve fiber bundle parameters, sensitivity of RTVue-OCT (64.6% to 84.8%) was consistently up to 35% higher (p

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