Comparison of bovine- and recombinant human-derived hyaluronidase with regard to fertilization rates and embryo morphology in a sibling oocyte model

a prospective, blinded, randomized study

Tyl H. Taylor, Thomas Elliott, Luiz F. Colturato, Robert J. Straub, Dorothy Mitchell-Leef, P. Nagy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The objective of the present study was to compare a traditionally used bovine-derived hyaluronidase (Hyase) with the newly developed recombinant human-derived enzyme product (Cumulase) in intracytoplasmic sperm injection (ICSI) procedures using a sibling oocyte model in a prospective randomized design. The results of the study demonstrate that Cumulase is safe and effective in an ICSI treatment program and can provide comparable if not improved parameters, including fertilization and embryo developmental rates.

Original languageEnglish
Pages (from-to)1544-1546
Number of pages3
JournalFertility and Sterility
Volume85
Issue number5
DOIs
Publication statusPublished - May 2006

Fingerprint

Hyaluronoglucosaminidase
Intracytoplasmic Sperm Injections
Fertilization
Oocytes
Embryonic Structures
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Comparison of bovine- and recombinant human-derived hyaluronidase with regard to fertilization rates and embryo morphology in a sibling oocyte model : a prospective, blinded, randomized study. / Taylor, Tyl H.; Elliott, Thomas; Colturato, Luiz F.; Straub, Robert J.; Mitchell-Leef, Dorothy; Nagy, P.

In: Fertility and Sterility, Vol. 85, No. 5, 05.2006, p. 1544-1546.

Research output: Contribution to journalArticle

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