Comparison of BAY e 5009 (nitrendipine) with dihydralazine in Wistar rats with experimentally induced nephritis

G. Mohacsi, S. Sonkodi

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2 Citations (Scopus)

Abstract

Chronic administration of nitrendipine (N) prevented the development of serious renal damage in Wistar rats with experimental glomerulonephritis. This effect is in sharp contrast with the action of dihydralazine (D). In the two treated groups, the blood pressure levels were in the same range and had returned to values of about 140 mm Hg. The heart rate and the increase in body weight were identical. Daily urinary protein excretion was significantly lower in the N-treated rats (p <0.001). During the experiment, 4 of the 12 D-treated and 6 of the 12 untreated animals died. In contrast, all of the N-treated rats survived. Their blood urea nitrogen and serum creatinine levels were significantly lower (p <0.01). Histologically, all untreated nephritic animals and three of eight D-treated rats revealed severe arteriopathy in the large vessels of the kidney and focal calcification of the glomerular and tubular basement membranes. Neither vascular changes nor basement membrane calcification were found in the kidneys of the N-treated group. These results suggest the direct renal prophylactic effect of N by prevention of the cellular calcium overload and the extracellular deposition of calcium.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume12
Issue numberSUPPL. 4
Publication statusPublished - 1988

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Dihydralazine
Nitrendipine
Nephritis
Wistar Rats
Kidney
Calcium
Glomerular Basement Membrane
Blood Urea Nitrogen
Glomerulonephritis
Basement Membrane
Blood Vessels
Creatinine
Heart Rate
Body Weight
Blood Pressure
Serum
Proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

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abstract = "Chronic administration of nitrendipine (N) prevented the development of serious renal damage in Wistar rats with experimental glomerulonephritis. This effect is in sharp contrast with the action of dihydralazine (D). In the two treated groups, the blood pressure levels were in the same range and had returned to values of about 140 mm Hg. The heart rate and the increase in body weight were identical. Daily urinary protein excretion was significantly lower in the N-treated rats (p <0.001). During the experiment, 4 of the 12 D-treated and 6 of the 12 untreated animals died. In contrast, all of the N-treated rats survived. Their blood urea nitrogen and serum creatinine levels were significantly lower (p <0.01). Histologically, all untreated nephritic animals and three of eight D-treated rats revealed severe arteriopathy in the large vessels of the kidney and focal calcification of the glomerular and tubular basement membranes. Neither vascular changes nor basement membrane calcification were found in the kidneys of the N-treated group. These results suggest the direct renal prophylactic effect of N by prevention of the cellular calcium overload and the extracellular deposition of calcium.",
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T1 - Comparison of BAY e 5009 (nitrendipine) with dihydralazine in Wistar rats with experimentally induced nephritis

AU - Mohacsi, G.

AU - Sonkodi, S.

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N2 - Chronic administration of nitrendipine (N) prevented the development of serious renal damage in Wistar rats with experimental glomerulonephritis. This effect is in sharp contrast with the action of dihydralazine (D). In the two treated groups, the blood pressure levels were in the same range and had returned to values of about 140 mm Hg. The heart rate and the increase in body weight were identical. Daily urinary protein excretion was significantly lower in the N-treated rats (p <0.001). During the experiment, 4 of the 12 D-treated and 6 of the 12 untreated animals died. In contrast, all of the N-treated rats survived. Their blood urea nitrogen and serum creatinine levels were significantly lower (p <0.01). Histologically, all untreated nephritic animals and three of eight D-treated rats revealed severe arteriopathy in the large vessels of the kidney and focal calcification of the glomerular and tubular basement membranes. Neither vascular changes nor basement membrane calcification were found in the kidneys of the N-treated group. These results suggest the direct renal prophylactic effect of N by prevention of the cellular calcium overload and the extracellular deposition of calcium.

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