Comparison of arterial stiffness parameters in patients with coronary artery disease and diabetes mellitus using Arteriograph

Z. Lenkey, M. Illyés, R. Böcskei, R. Husznai, Z. Sárszegi, Z. Meiszterics, F. T. Molnár, G. Hild, S. Szabados, A. Cziráki, B. Gaszner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recently an expert consensus document advised to standardize user procedures and a new cut-offvalue for carotid-femoral pulse wave velocity in daily practice. Our aim was to observe aortic pulse wave velocity (PWVao) and augmentation index (AIXao) in two high cardiovascular risk groups: patients with verified coronary artery disease (CAD) or with type 2 diabetes mellitus (T2DM). We also aimed to determine the cut-offvalues for PWVao, AIXao in CAD and T2DM patients using oscillometric device (Arteriograph). We investigated 186 CAD and 152 T2DM patients. PWVao and AIXao increased significantly in the CAD group compared to the age-, gender-, blood pressure-, and heart rate-matched control group (10.2±2.3 vs. 9.3±1.5 m/s; p<0.001 and 34.9±14.6 vs. 31.9±12.8 %; p<0.05, respectively). When compared to the apparently healthy control subjects, T2DM patients had significantly elevated PWVao (9.7±1.7 vs. 9.3±1.5 m/s; p<0.05, respectively), however the AIXao did not differ significantly. The ROC-curves of CAD and healthy control subjects explored cut-offvalues of 10.2 m/s for PWVao and 33.23 % for AIXao. Our data provide supporting evidence about impaired arterial stiffness parameters in CAD and T2DM. Our findings encourage the implementation of arterial stiffness measurements by oscillometric method in daily clinical routine.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalPhysiological Research
Volume63
Issue number4
Publication statusPublished - Jan 1 2014

Keywords

  • Arterial stiffness
  • Coronary heart disease
  • Cut-offvalue
  • Diabetes mellitus

ASJC Scopus subject areas

  • Physiology

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    Lenkey, Z., Illyés, M., Böcskei, R., Husznai, R., Sárszegi, Z., Meiszterics, Z., Molnár, F. T., Hild, G., Szabados, S., Cziráki, A., & Gaszner, B. (2014). Comparison of arterial stiffness parameters in patients with coronary artery disease and diabetes mellitus using Arteriograph. Physiological Research, 63(4), 429-437.