Abstract
INTRODUCTION: Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS: mRNA expression of adipokines; adiponectin, resistin, tumour necrosis factor-a, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, and cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. RESULTS: We did not find any significant difference in the investigated genes; however, the almost significant overexpression of AGT and underexpression of IL-6 might be noteworthy (p = 0.06 in both cases). CONCLUSIONS: No significant differences were found in the expression of the investigated genes known as cardiometabolic risk factors. This indicates that there are no major differences between endogenous hypercortisolism or diet-induced obesity regarding the expression of adipokines involved in cardiometabolic disorders. However, the difference in AGT and IL-6 expression might be included in pathways affecting fat distribution in CS.
| Original language | English |
|---|---|
| Pages (from-to) | 131-134 |
| Number of pages | 4 |
| Journal | Endokrynologia Polska |
| Volume | 70 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- adipokines
- Cushing’s syndrome
- glucocorticoids
- obesity
- visceral adipose tissue
ASJC Scopus subject areas
- Endocrinology
Cite this
Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity. / Denes, Judit; Zsippai, Adrienn; Kovacs, Laszlo; Gorombey, Zoltan; Kovacs, Gabor L.; Góth, M.; Igaz, P.; Hubina, Erika.
In: Endokrynologia Polska, Vol. 70, No. 2, 01.01.2019, p. 131-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity
AU - Denes, Judit
AU - Zsippai, Adrienn
AU - Kovacs, Laszlo
AU - Gorombey, Zoltan
AU - Kovacs, Gabor L.
AU - Góth, M.
AU - Igaz, P.
AU - Hubina, Erika
PY - 2019/1/1
Y1 - 2019/1/1
N2 - INTRODUCTION: Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS: mRNA expression of adipokines; adiponectin, resistin, tumour necrosis factor-a, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, and cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. RESULTS: We did not find any significant difference in the investigated genes; however, the almost significant overexpression of AGT and underexpression of IL-6 might be noteworthy (p = 0.06 in both cases). CONCLUSIONS: No significant differences were found in the expression of the investigated genes known as cardiometabolic risk factors. This indicates that there are no major differences between endogenous hypercortisolism or diet-induced obesity regarding the expression of adipokines involved in cardiometabolic disorders. However, the difference in AGT and IL-6 expression might be included in pathways affecting fat distribution in CS.
AB - INTRODUCTION: Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS: mRNA expression of adipokines; adiponectin, resistin, tumour necrosis factor-a, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, and cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. RESULTS: We did not find any significant difference in the investigated genes; however, the almost significant overexpression of AGT and underexpression of IL-6 might be noteworthy (p = 0.06 in both cases). CONCLUSIONS: No significant differences were found in the expression of the investigated genes known as cardiometabolic risk factors. This indicates that there are no major differences between endogenous hypercortisolism or diet-induced obesity regarding the expression of adipokines involved in cardiometabolic disorders. However, the difference in AGT and IL-6 expression might be included in pathways affecting fat distribution in CS.
KW - adipokines
KW - Cushing’s syndrome
KW - glucocorticoids
KW - obesity
KW - visceral adipose tissue
UR - http://www.scopus.com/inward/record.url?scp=85065471571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065471571&partnerID=8YFLogxK
U2 - 10.5603/EP.a2018.0091
DO - 10.5603/EP.a2018.0091
M3 - Article
C2 - 30480750
AN - SCOPUS:85065471571
VL - 70
SP - 131
EP - 134
JO - Endokrynologia Polska
JF - Endokrynologia Polska
SN - 0423-104X
IS - 2
ER -