Comparison between PACAP- and enriched environment-induced retinal protection in MSG-treated newborn rats

P. Kiss, Tamas Atlasz, K. Szabadfi, Gabor Horvath, Monika Griecs, Jozsef Farkas, Attila Matkovits, G. Tóth, A. Lubics, A. Tamás, R. Gábriel, D. Reglodi

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16 Citations (Scopus)

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors occur throughout the nervous system, including the retina. PACAP exerts diverse actions in the eye: it influences ocular blood flow, contraction of the ciliary muscle, and has retinoprotective effects. This effect has been proven in different models of retinal degeneration. We have previously shown that PACAP protects against monosodium-glutamate (MSG)-induced damage in neonatal rats. The beneficial effects of enriched environment, another neuroprotective strategy, have long been known. Environmental enrichment has been shown to decrease different neuronal injuries. It also influences the development of the visual system. We have recently demonstrated that significant neuroprotection can be achieved in MSG-induced retinal degeneration in animals kept in an enriched environment. Combination of neuroprotective strategies often results in increased protection. Therefore, the aim of the present study was to compare the two neuroprotective strategies alone and in combination therapy. We found that both PACAP and environmental enrichment led to a similar degree of retinal protection, but the two treatments together did not lead to increased protection: their effects were not additive.

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalNeuroscience Letters
Volume487
Issue number3
DOIs
Publication statusPublished - Jan 10 2011

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Sodium Glutamate
Retinal Degeneration
Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
Muscle Contraction
Nervous System
Retina
Wounds and Injuries
Therapeutics

Keywords

  • Development
  • Environmental enrichment
  • Excitotoxicity
  • Neurotrophic factor
  • Retinoprotection

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Comparison between PACAP- and enriched environment-induced retinal protection in MSG-treated newborn rats. / Kiss, P.; Atlasz, Tamas; Szabadfi, K.; Horvath, Gabor; Griecs, Monika; Farkas, Jozsef; Matkovits, Attila; Tóth, G.; Lubics, A.; Tamás, A.; Gábriel, R.; Reglodi, D.

In: Neuroscience Letters, Vol. 487, No. 3, 10.01.2011, p. 400-405.

Research output: Contribution to journalArticle

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