Comparison between magnetic resonance imaging estimates of extracranial cerebrospinal fluid volume and physical measurements in healthy dogs

László Z. Reinitz, Gábor Bajzik, Rita Garamvölgyi, Örs Petneházy, András Lassó, Zsolt Abonyi-Tóth, Borbála Lorincz, P. Sótonyi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dosages for myelography procedures in dogs are based on a hypothetical proportional relationship between bodyweight and cerebrospinal fluid (CSF) volume. Anecdotal radiographic evidence and recent studies have challenged the existence of such a defined relationship in dogs. The objectives of this prospective cross-sectional study were to describe CSF volumes using magnetic resonance imaging (MRI) in a group of clinically healthy dogs, measure the accuracy of MRI CSF volumes, and compare MRI CSF volumes with dog physical measurements. A sampling perfection with application optimized contrast using different flip-angle evolution MRI examination of the central nervous system was carried out on 12 healthy, male mongrel dogs, aged between 3 and 5 years with a bodyweight range of 7.5-35.0 kg. The images were processed with image analysis freeware (3D Slicer) in order to calculate the volume of extracranial CSF. Cylindrical phantoms of known volume were included in scans and used to calculate accuracy of MRI volume estimates. The accuracy of MRI volume estimates was 99.8%. Extracranial compartment CSF volumes ranged from 20.21 to 44.06 ml. Overall volume of the extracranial CSF increased linearly with bodyweight, but the proportional volume (ml/bodyweight kilograms) of the extracranial CSF was inversely proportional to bodyweight. Relative ratios of volumes in the cervical, thoracic, and lumbosacral regions were constant. Findings indicated that the current standard method of using body weight to calculate dosages of myelographic contrast agents in dogs may need to be revised.

Original languageEnglish
Pages (from-to)658-665
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume56
Issue number6
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

cerebrospinal fluid
magnetic resonance imaging
Cerebrospinal Fluid
Magnetic Resonance Imaging
Dogs
dogs
body weight
Lumbosacral Region
Myelography
Contrast Media
Thorax
Central Nervous System
Cross-Sectional Studies
Body Weight
chest
dosage
cross-sectional studies
central nervous system
image analysis

Keywords

  • Cerebrospinal fluid
  • CSF
  • Dog
  • Extracranial
  • Subarachnoid space
  • Volume

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparison between magnetic resonance imaging estimates of extracranial cerebrospinal fluid volume and physical measurements in healthy dogs. / Reinitz, László Z.; Bajzik, Gábor; Garamvölgyi, Rita; Petneházy, Örs; Lassó, András; Abonyi-Tóth, Zsolt; Lorincz, Borbála; Sótonyi, P.

In: Veterinary Radiology and Ultrasound, Vol. 56, No. 6, 01.11.2015, p. 658-665.

Research output: Contribution to journalArticle

Reinitz, László Z. ; Bajzik, Gábor ; Garamvölgyi, Rita ; Petneházy, Örs ; Lassó, András ; Abonyi-Tóth, Zsolt ; Lorincz, Borbála ; Sótonyi, P. / Comparison between magnetic resonance imaging estimates of extracranial cerebrospinal fluid volume and physical measurements in healthy dogs. In: Veterinary Radiology and Ultrasound. 2015 ; Vol. 56, No. 6. pp. 658-665.
@article{ccbdead4274142e98c5754013d081ce6,
title = "Comparison between magnetic resonance imaging estimates of extracranial cerebrospinal fluid volume and physical measurements in healthy dogs",
abstract = "Dosages for myelography procedures in dogs are based on a hypothetical proportional relationship between bodyweight and cerebrospinal fluid (CSF) volume. Anecdotal radiographic evidence and recent studies have challenged the existence of such a defined relationship in dogs. The objectives of this prospective cross-sectional study were to describe CSF volumes using magnetic resonance imaging (MRI) in a group of clinically healthy dogs, measure the accuracy of MRI CSF volumes, and compare MRI CSF volumes with dog physical measurements. A sampling perfection with application optimized contrast using different flip-angle evolution MRI examination of the central nervous system was carried out on 12 healthy, male mongrel dogs, aged between 3 and 5 years with a bodyweight range of 7.5-35.0 kg. The images were processed with image analysis freeware (3D Slicer) in order to calculate the volume of extracranial CSF. Cylindrical phantoms of known volume were included in scans and used to calculate accuracy of MRI volume estimates. The accuracy of MRI volume estimates was 99.8{\%}. Extracranial compartment CSF volumes ranged from 20.21 to 44.06 ml. Overall volume of the extracranial CSF increased linearly with bodyweight, but the proportional volume (ml/bodyweight kilograms) of the extracranial CSF was inversely proportional to bodyweight. Relative ratios of volumes in the cervical, thoracic, and lumbosacral regions were constant. Findings indicated that the current standard method of using body weight to calculate dosages of myelographic contrast agents in dogs may need to be revised.",
keywords = "Cerebrospinal fluid, CSF, Dog, Extracranial, Subarachnoid space, Volume",
author = "Reinitz, {L{\'a}szl{\'o} Z.} and G{\'a}bor Bajzik and Rita Garamv{\"o}lgyi and {\"O}rs Petneh{\'a}zy and Andr{\'a}s Lass{\'o} and Zsolt Abonyi-T{\'o}th and Borb{\'a}la Lorincz and P. S{\'o}tonyi",
year = "2015",
month = "11",
day = "1",
doi = "10.1111/vru.12283",
language = "English",
volume = "56",
pages = "658--665",
journal = "Veterinary Radiology and Ultrasound",
issn = "1058-8183",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Comparison between magnetic resonance imaging estimates of extracranial cerebrospinal fluid volume and physical measurements in healthy dogs

AU - Reinitz, László Z.

AU - Bajzik, Gábor

AU - Garamvölgyi, Rita

AU - Petneházy, Örs

AU - Lassó, András

AU - Abonyi-Tóth, Zsolt

AU - Lorincz, Borbála

AU - Sótonyi, P.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Dosages for myelography procedures in dogs are based on a hypothetical proportional relationship between bodyweight and cerebrospinal fluid (CSF) volume. Anecdotal radiographic evidence and recent studies have challenged the existence of such a defined relationship in dogs. The objectives of this prospective cross-sectional study were to describe CSF volumes using magnetic resonance imaging (MRI) in a group of clinically healthy dogs, measure the accuracy of MRI CSF volumes, and compare MRI CSF volumes with dog physical measurements. A sampling perfection with application optimized contrast using different flip-angle evolution MRI examination of the central nervous system was carried out on 12 healthy, male mongrel dogs, aged between 3 and 5 years with a bodyweight range of 7.5-35.0 kg. The images were processed with image analysis freeware (3D Slicer) in order to calculate the volume of extracranial CSF. Cylindrical phantoms of known volume were included in scans and used to calculate accuracy of MRI volume estimates. The accuracy of MRI volume estimates was 99.8%. Extracranial compartment CSF volumes ranged from 20.21 to 44.06 ml. Overall volume of the extracranial CSF increased linearly with bodyweight, but the proportional volume (ml/bodyweight kilograms) of the extracranial CSF was inversely proportional to bodyweight. Relative ratios of volumes in the cervical, thoracic, and lumbosacral regions were constant. Findings indicated that the current standard method of using body weight to calculate dosages of myelographic contrast agents in dogs may need to be revised.

AB - Dosages for myelography procedures in dogs are based on a hypothetical proportional relationship between bodyweight and cerebrospinal fluid (CSF) volume. Anecdotal radiographic evidence and recent studies have challenged the existence of such a defined relationship in dogs. The objectives of this prospective cross-sectional study were to describe CSF volumes using magnetic resonance imaging (MRI) in a group of clinically healthy dogs, measure the accuracy of MRI CSF volumes, and compare MRI CSF volumes with dog physical measurements. A sampling perfection with application optimized contrast using different flip-angle evolution MRI examination of the central nervous system was carried out on 12 healthy, male mongrel dogs, aged between 3 and 5 years with a bodyweight range of 7.5-35.0 kg. The images were processed with image analysis freeware (3D Slicer) in order to calculate the volume of extracranial CSF. Cylindrical phantoms of known volume were included in scans and used to calculate accuracy of MRI volume estimates. The accuracy of MRI volume estimates was 99.8%. Extracranial compartment CSF volumes ranged from 20.21 to 44.06 ml. Overall volume of the extracranial CSF increased linearly with bodyweight, but the proportional volume (ml/bodyweight kilograms) of the extracranial CSF was inversely proportional to bodyweight. Relative ratios of volumes in the cervical, thoracic, and lumbosacral regions were constant. Findings indicated that the current standard method of using body weight to calculate dosages of myelographic contrast agents in dogs may need to be revised.

KW - Cerebrospinal fluid

KW - CSF

KW - Dog

KW - Extracranial

KW - Subarachnoid space

KW - Volume

UR - http://www.scopus.com/inward/record.url?scp=84955206080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955206080&partnerID=8YFLogxK

U2 - 10.1111/vru.12283

DO - 10.1111/vru.12283

M3 - Article

VL - 56

SP - 658

EP - 665

JO - Veterinary Radiology and Ultrasound

JF - Veterinary Radiology and Ultrasound

SN - 1058-8183

IS - 6

ER -